Effects of supplementation with low-dose group B vitamins on clinical and biochemical parameters in critically ill patients with COVID-19: a randomized clinical trial.

IF 4.2 2区医学 Q1 INFECTIOUS DISEASES

Expert Review of Anti-infective Therapy Pub Date : 2024-07-01 Epub Date: 2022-09-28 DOI:10.1080/14787210.2022.2125867

Nazanin Majidi, Effat Bahadori, Soheila Shekari, Maryam Gholamalizadeh, Shirin Tajadod, Marjan Ajami, Somayeh Gholami, Mahdi Shadnoush, Mina Ahmadzadeh, Anoush Dehnadi Moghadam, Naeemeh Hassanpour Ardekanizadeh, Hanieh Shafaei Kachaei, Fatemeh Shafie, Alireza Moslem, Saeid Doaei, Mark O Goodarzi

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引用次数: 0

Abstract

Background: : This study aimed to check the effect of supplementation with low-dose group B vitamins on clinical and biochemical parameters on patients with coronavirus disease 2019 (COVID-19).

Research design and method: : This double-blind, randomized clinical trial was carried out on 85 critically ill patients with COVID-19. All patients received high protein prescriptions of 30 kcal/kg/d by enteral nutrition. The intervention group (n = 40) received vitamin B complex, including thiamine (10 mg), riboflavin (4 mg), nicotinamide (40 mg), and dexpanthenol (6 mg). The control group received similar nutritional supports, except for group B vitamins. Assessments were carried out at baseline and after 2 weeks of intervention.

Results: : Vitamin B supplementation had no effects on the biochemical and pathological parameters including kidney function, arterial blood gas parameters, Glasgow coma scale, cell blood count, and serum electrolytes of the intervention group compared with the control group. The 30-day mortality was insignificantly lower in the intervention group than in the control group (83.3% against 96.1%, P = 0.07).

Conclusions: The mortality rate of patients with COVID-19 might be improved by low-dose vitamin B supplementation.

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补充小剂量 B 族维生素对 COVID-19 重症患者临床和生化指标的影响：随机临床试验。

研究背景：：本研究旨在检测补充低剂量B族维生素对2019年冠状病毒病（COVID-19）患者临床和生化指标的影响：这项双盲随机临床试验针对 85 名 COVID-19 重症患者展开。所有患者均通过肠内营养接受 30 千卡/千克/天的高蛋白处方。干预组（n = 40）接受复合维生素 B，包括硫胺素（10 毫克）、核黄素（4 毫克）、烟酰胺（40 毫克）和脱泛醇（6 毫克）。对照组接受类似的营养支持，但 B 组维生素除外。评估在基线和干预 2 周后进行：与对照组相比，补充维生素 B 对干预组的生化和病理参数（包括肾功能、动脉血气参数、格拉斯哥昏迷量表、细胞血细胞计数和血清电解质）没有影响。干预组的 30 天死亡率显著低于对照组（83.3% 对 96.1%，P = 0.07）：结论：通过补充小剂量维生素 B，COVID-19 患者的死亡率可能会有所改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anti-infective Therapy 医学-药学

CiteScore

11.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.