The prognosis of pre-frail chronic obstructive pulmonary disease patients for hospitalizations and mortality depends on their level of functional physical performance.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Francesc Medina-Mirapeix, Roberto Bernabeu-Mora, Mariano Gacto-Sánchez, Joaquina Montilla-Herrador, Pilar Escolar-Reina, María Piedad Sánchez-Martínez
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引用次数: 1

Abstract

Objective: To determine if pre-frail Chronic obstructive pulmonary disease (COPD) patients with poor and non-poor performance in the five-repetition sit-to-stand test (5-STS) had a worse prognosis for hospitalization and mortality at 2 years and for mortality at 5 years than non-frail patients.

Methods: We prospectively included patients with stable COPD, between 40 and 80 years, from a hospital in Spain. Patients were classified according their performance on the 5-STS test and level of frailty. Timing, number of hospitalizations, length of stay, and timing and rate of mortality were outcome measures. Patients were followed for 2 years for exacerbations and for 5 years for mortality. Kaplan-Meier curves and univariate and multivariate Cox proportional-hazard analyses, ANOVA tests and univariate and multivariate linear and logistic regression models were used.

Results: Of the 125 patients included, 25.6% were pre-frail with poor performance, 57% pre-frail with non-poor performance, and 17.4% non-frail with non-poor performance. Pre-frail patients with poor performance had a higher number of hospitalizations (adjusted beta: 0.49; 95% CI: 0.01-0.96), mortality rates (odds ratio: 11.33; 95% CI: 1.15-110.81), and risk at 5 years (adjusted hazard ratio: 8.77; 95% CI: 1.02-75.51) than non-frail patients. Pre-frail patients with poor performance also had worse prognoses than non-frail patients with respect to length of hospital stays (increased by 4.16 days) and timing to first hospitalization (HR: 6.01) in unadjusted models, but not when adjusted.

Conclusion: The COPD prognosis of pre-frail patients with respect to the number of exacerbations with hospitalization and the timing and rate of mortality is dependent of functional performance.

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体弱前慢性阻塞性肺疾病患者的住院预后和死亡率取决于他们的功能性身体表现水平。
目的:确定在五次重复坐立测试(5- sts)中表现不佳和不佳的虚弱前慢性阻塞性肺疾病(COPD)患者的住院预后和2年死亡率以及5年死亡率是否比非虚弱患者更差。方法:我们前瞻性地纳入了来自西班牙一家医院的40 - 80岁的稳定期COPD患者。根据患者在5-STS测试中的表现和虚弱程度对患者进行分类。时间、住院次数、住院时间、时间和死亡率是结局指标。病情恶化随访2年,死亡随访5年。Kaplan-Meier曲线、单因素和多因素Cox比例风险分析、ANOVA检验、单因素和多因素线性和逻辑回归模型。结果:纳入的125例患者中,25.6%为体弱前期表现不佳,57%为体弱前期表现不佳,17.4%为体弱前期表现不佳。表现不佳的体弱前患者住院次数较高(调整贝塔系数:0.49;95% CI: 0.01-0.96),死亡率(优势比:11.33;95% CI: 1.15-110.81), 5年风险(校正风险比:8.77;95% CI: 1.02-75.51)。在未调整模型中,表现不佳的体弱前期患者在住院时间(增加4.16天)和首次住院时间(HR: 6.01)方面的预后也比非体弱患者差,但在调整模型中则不是这样。结论:虚弱前期COPD患者的预后与住院加重次数、住院时间和死亡率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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