Plasma glial fibrillary acidic protein and neurofilament light chain in relation to disability worsening in multiple sclerosis.

Ayla Pauwels, Jeroen Van Schependom, Lindsay Devolder, Ann Van Remoortel, Guy Nagels, Maria Bjerke, Marie B D'hooghe
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引用次数: 7

Abstract

Background: Predicting disability worsening in multiple sclerosis (MS) remains an important challenge. Glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) seem promising biomarkers. Studies investigating blood GFAP in relation to longitudinal outcome measures in MS are scarce.

Objective: To compare plasma-GFAP (p-GFAP) and plasma-NfL (p-NfL) levels in relation to sustained disability worsening.

Methods: We measured baseline p-GFAP and p-NfL in a prospective cohort of 115 individuals with MS and 30 matched controls, using Single Molecule Array (Simoa). Disability worsening was defined as an increase in at least one of three measures (Expanded Disability Status Scale, Timed 25-foot walk, 9-Hole Peg test), confirmed after 6 months and persistent upon data closure.

Results: In a multivariable Cox proportional-hazards model, p-GFAP was not significantly associated with sustained disability worsening after 4.40 ± 0.82 years, while p-NfL (HR = 1.046, p = 0.001), EDSS (HR = 1.24, p = 0.039), and disease duration (HR = 1.048, p = 0.017) were. Area under the curve of ROC curves in relation to worsening was 0.61 for p-GFAP (p = 0.031) and 0.63 for p-NfL (p = 0.015). Kaplan-Meier curves showed similar patterns for both proteins.

Conclusion: p-NfL emerged as a significant explanatory variable for worsening in Cox regression analysis, and p-GFAP did not. Both p-GFAP and p-NfL were related to worsening based on ROC curves.

血浆胶质原纤维酸性蛋白和神经丝轻链与多发性硬化症残疾恶化的关系。
背景:预测多发性硬化症(MS)的残疾恶化仍然是一个重要的挑战。胶质纤维酸性蛋白(GFAP)和神经丝轻链(NfL)是很有前景的生物标志物。研究血液GFAP与多发性硬化症纵向结果测量的关系很少。目的:比较血浆gfap (p-GFAP)和血浆nfl (p-NfL)水平与持续残疾恶化的关系。方法:我们使用单分子阵列(Simoa)测量了115名MS患者和30名匹配对照者的基线p-GFAP和p-NfL。残疾恶化定义为三项测量(扩展残疾状态量表,定时25英尺步行,9孔钉测试)中至少一项的增加,在6个月后确认,并在数据关闭时持续存在。结果:在多变量Cox比例风险模型中,p- gfap与4.40±0.82年后持续残疾恶化无显著相关性,而p- nfl (HR = 1.046, p = 0.001)、EDSS (HR = 1.24, p = 0.039)和病程(HR = 1.048, p = 0.017)与持续残疾恶化有显著相关性。与恶化相关的ROC曲线下面积p- gfap为0.61 (p = 0.031), p- nfl为0.63 (p = 0.015)。Kaplan-Meier曲线显示了两种蛋白质的相似模式。结论:在Cox回归分析中,p-NfL是病情恶化的重要解释变量,而p-GFAP则不是。根据ROC曲线,p-GFAP和p-NfL均与恶化相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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