Influence of alumina substrates open porosity on calcium phosphates formation produced by the biomimetic method.

IF 4.4 3区医学 Q2 ENGINEERING, BIOMEDICAL

Progress in Biomaterials Pub Date : 2022-09-01 Epub Date: 2022-06-23 DOI:10.1007/s40204-022-00193-8

Isabela R Lavagnini, João V Campos, Denise Osiro, Julieta A Ferreira, Luiz A Colnago, Eliria M J A Pallone

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引用次数: 1

Abstract

We evaluated the influence of the open porosity of alumina (Al₂O₃) substrates on the phase formation of calcium phosphates deposited onto it surface. The Al₂O₃ substrates were prepared with different porosities by the foam-gelcasting method associated with different amounts of polyethylene beads. The substrates were coated biomimetically for 14 and 21 days of incubation in a simulated body fluid (SBF). Scanning electron microscopy characterisation and X-ray computed microtomography showed that the increase in the number of beads provided an increase in the open porosity. The X-ray diffraction and infrared spectroscopy showed that the biomimetic method was able to form different phases of calcium phosphates. It was observed that the increase in the porosity favoured the formation of β-tricalcium phosphate for both incubation periods. The incubation period and the porosity of the substrates can influence the phases and the amount of calcium phosphates formed. Thus, it is possible to target the best application for the biomaterial produced.

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氧化铝基质开孔率对仿生方法制备磷酸钙的影响。

我们评估了氧化铝(Al2O3)衬底的开孔率对沉积在其表面的磷酸钙相形成的影响。采用泡沫-凝胶铸法制备了不同孔隙率的Al2O3基板，并添加了不同数量的聚乙烯微球。在模拟体液(SBF)中对底物进行仿生包被，孵育14天和21天。扫描电子显微镜表征和x射线计算机显微断层扫描显示，珠子数量的增加提供了开放孔隙度的增加。x射线衍射和红外光谱分析表明，仿生方法能够形成不同相的磷酸钙。观察到孔隙度的增加有利于β-磷酸三钙在两个潜伏期的形成。孵育时间和基质的孔隙率会影响形成的磷酸钙的相和数量。因此，可以针对所生产的生物材料的最佳应用。

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来源期刊

Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

9.60

自引率

4.10%

发文量

期刊介绍： Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.