A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin.

IF 1.8 3区医学 Q4 TOXICOLOGY

Journal of Venomous Animals and Toxins Including Tropical Diseases Pub Date : 2022-03-14 eCollection Date: 2022-01-01 DOI:10.1590/1678-9199-JVATITD-2021-0067

Mackson Martins Rocha, Isabela Dariva, Gabriela Comelli Zornoff, Giovanna Sanches De Laurentis, Giulia Carli Mendes, Maycon Giovani Santana, Guilherme Chohfi de Miguel, Rui Seabra Ferreira, Juliana Mozer Sciani, Denise Gonçalves Priolli

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引用次数: 3

Abstract

Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer.

Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated.

Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed.

Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.

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一种治疗结直肠癌骨转移的新方法:瘤内蜂毒素。

背景:蜂毒素对肿瘤细胞有抗增殖作用。因此，它包含一种有价值的化合物，用于研究癌症治疗。据我们所知，没有研究报道蜂毒素对骨转移的影响。在此，我们提出一种基于转移内注射蜂毒素治疗结直肠癌骨转移的方法。方法:根据蜂毒素的特性和体外抗增殖试验，通过转移内途径单剂量注射小鼠骨转移模型。治疗后，评估转移生长情况。结果:单剂量蜂毒素能抑制转移生长。组织学分析显示蜂毒素治疗的转移灶坏死和炎症过程。除了轻微的体重减轻外，没有观察到其他的全身效应。结论:我们的数据提示蜂毒素可能是未来开发治疗策略的一个有希望的药物，旨在减少骨转移对结直肠癌骨转移患者骨骼相关的影响。

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来源期刊

Journal of Venomous Animals and Toxins Including Tropical Diseases 医学-毒理学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.