Associations between AGT M235T Polymorphism and Cancer: An Updated Meta-Analysis.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2022-03-04 eCollection Date: 2022-01-01 DOI:10.1155/2022/7862709

Junyan Kou, Jing Huang

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引用次数: 0

Abstract

We assessed the relationship between AGT gene M235T polymorphism and the susceptibility to cancer by performing an updated meta-analysis. This study retrospectively searched related articles in the electronic databases. Afterwards, we determined combined odds ratios (ORs) and related 95% confidence intervals (CIs) by the fixed- or random-effects model. The present meta-analysis enrolled altogether 9 articles. On the whole, the relationship between AGT M235T polymorphism and the cancer risk was not significant among the entire population (TT vs. MM: OR = 1.28, 95%CI = 0.80 - 2.04; TM vs. MM: OR = 0.90, 95%CI = 0.53 - 1.52; recessive model: OR = 1.13, 95%CI = 0.83 - 1.52; dominant model: OR = 0.93, 95%CI = 0.55 - 1.57). Subgroup analysis by ethnicity, cancer type, and study quality for the relationship between the AGT M235T polymorphism and cancer risk showed no significant association. According to findings in the present meta-analysis, AGT M235T polymorphism may not be related to cancer susceptibility.

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AGT M235T多态性与癌症之间的关系:一项最新的荟萃分析

我们通过进行一项更新的荟萃分析来评估AGT基因M235T多态性与癌症易感性之间的关系。本研究回顾性检索了电子数据库中的相关文章。随后，我们通过固定效应或随机效应模型确定了组合优势比(ORs)和相关95%置信区间(CIs)。本荟萃分析共纳入9篇文章。总体而言，AGT M235T多态性与整个人群癌症风险的关系不显著(TT vs. MM: OR = 1.28, 95%CI = 0.80 ~ 2.04;TM vs. MM: OR = 0.90, 95%CI = 0.53 ~ 1.52;隐性模型:OR = 1.13, 95%CI = 0.83 ~ 1.52;优势模型:OR = 0.93, 95%CI = 0.55 ~ 1.57)。按种族、癌症类型和研究质量进行的AGT M235T多态性与癌症风险关系的亚组分析显示没有显著相关性。根据本荟萃分析的发现，AGT M235T多态性可能与癌症易感性无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.