Combined Central and Peripheral Demyelination With IgM Anti-Neurofascin 155 Antibodies: Case Report.

IF 7.5

Neurology(R) neuroimmunology & neuroinflammation Pub Date : 2022-03-21 Print Date: 2022-05-01 DOI:10.1212/NXI.0000000000001160

Antoine Pegat, Emilien Delmont, Juliette Svahn, Emilien Bernard, Lola Lessard, Romain Marignier, Francoise Bouhour

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引用次数: 1

Abstract

Immunoglobulin (Ig) G anti – neurofascin 155 antibodies (anti-NF155 Abs) have been described in rare forms of chronic in ﬂ ammatory demyelinating polyradiculoneuropathy (CIDP) and in combined central and peripheral demyelination (CCPD). 1 We report herein a case of a patient presenting CCPD and IgM anti-NF155 Ab. quadridistal hypesthesia, gait, tendon re ﬂ exes. Overall Neuropathy Limitations (ONLS) was 1/12. Electroneuromyography (ENMG) revealed a di ﬀ use homogeneous demyelinating neuropathy. Nerve ultrasonography and of the cervical plexus 1, D and a di ﬀ use enlargement of peripheral structures. CSF analysis showed elevated protein level (0.7 g/L, normal <0.4) and 14 white blood cells/mm 3 (normal <2) with oligoclonal IgG bands. Cerebral MRI revealed multiple hyperintensities in the periventricular and juxtacortical white matter (diagnosis of radiologically isolated syn-drome). All the 97 genes of a panel of genes involved in hereditary neuropathies, especially demyelinating Charcot-Marie-Tooth (CMT), were negative. Peripheral

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