Advances in Liver Transplantation for Persons with Human Immunodeficiency Infection.

IF 3.1 4区医学 Q2 INFECTIOUS DISEASES

Current Infectious Disease Reports Pub Date : 2022-01-01 Epub Date: 2022-03-15 DOI:10.1007/s11908-022-00776-3

Rebecca N Kumar, Valentina Stosor

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引用次数: 1

Abstract

Purpose of review: Advanced liver disease is a leading cause of non-AIDS-related morbidity and mortality in persons with HIV on antiretroviral therapy. As a result, persons with HIV are increasingly seeking liver transplantation.

Recent findings: With the availability of direct-acting antiviral hepatitis C therapies, there has been a shift in the indications for liver transplantation in persons with HIV, with non-alcoholic fatty liver disease now the leading indication over hepatitis C infection. Additionally, liver transplant outcomes have improved in persons with HIV-hepatitis C co-infection persons with HIV. Preliminary results of HIV-to-HIV liver transplantation show acceptable results although rates of post-transplant infections and malignancies are areas of concern.

Summary: Future studies of liver transplantation in persons with HIV should focus on long-term outcomes, especially in the context of steatohepatitis and co-existing morbidities like diabetes, hyperlipidemia, and cardiovascular disease and other prevalent diseases in an aging population.

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人类免疫缺陷感染者肝移植的研究进展。

综述目的:晚期肝病是接受抗逆转录病毒治疗的艾滋病毒感染者非艾滋病相关发病率和死亡率的主要原因。因此，越来越多的艾滋病毒感染者寻求肝移植。最近的发现:随着直接作用的丙型肝炎抗病毒治疗的可用性，HIV感染者肝移植的适应症发生了变化，非酒精性脂肪性肝病现在是丙型肝炎感染的主要适应症。此外，HIV-丙型肝炎合并感染HIV患者的肝移植结果也有所改善。hiv - hiv肝移植的初步结果显示出可以接受的结果，尽管移植后的感染率和恶性肿瘤是值得关注的领域。摘要:未来对HIV感染者肝移植的研究应关注长期结果，特别是在脂肪性肝炎和并发疾病如糖尿病、高脂血症、心血管疾病和其他老龄化人群中流行疾病的背景下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Infectious Disease Reports INFECTIOUS DISEASES-

CiteScore

6.70

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of infectious disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as HIV/AIDS, sexually transmitted diseases, tropical and travel medicine, and urinary tract infections. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists.