Eline van der Valk, Tom Tobe, Aline Stades, Alex Muller
{"title":"Vanishing hypercalciuric kidney stones after treating underlying acromegaly.","authors":"Eline van der Valk, Tom Tobe, Aline Stades, Alex Muller","doi":"10.1530/EDM-13-0001","DOIUrl":null,"url":null,"abstract":"<p><strong>Unlabelled: </strong>A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given.</p><p><strong>Learning points: </strong>Hypercalciuria is a common finding in acromegaly.There are only few reports describing hypercalciuric kidney stones in acromegaly.We assume that in acromegaly there is a primary role of IGF1-mediated, PTH-independent increase in calcitriol synthesis resulting in hypercalciuric kidney stones.</p>","PeriodicalId":520608,"journal":{"name":"Endocrinology, diabetes & metabolism case reports","volume":" ","pages":"130001"},"PeriodicalIF":0.7000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921684/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, diabetes & metabolism case reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/EDM-13-0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/7/1 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Unlabelled: A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given.
Learning points: Hypercalciuria is a common finding in acromegaly.There are only few reports describing hypercalciuric kidney stones in acromegaly.We assume that in acromegaly there is a primary role of IGF1-mediated, PTH-independent increase in calcitriol synthesis resulting in hypercalciuric kidney stones.
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