Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals

Results in immunology Pub Date : 2013-01-01 DOI:10.1016/j.rinim.2013.01.001

André L.L. Bachi , Vinicius M. Suguri , Luiz Roberto Ramos , Mario Mariano , Mauro Vaisberg , Jose D. Lopes

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引用次数: 45

Abstract

Immunosenescence is associated to aging and among many changes in immune response is reported a reduced response to vaccination and an increase in the number of cases of autoimmunity, caused by autoantibodies known as natural antibodies whose function, according to reports, would be protection against infection and inflammation. Although immunosenescence is an irreversible process, regular moderate exercise can attenuate some aspects of the decline in the immune system. So, the aim of this study was to investigate the humoral immune response in physically active elderly individuals before and 30 days after vaccination against influenza virus. The results showed that the percentage of individuals positive for antinuclear antibodies and serum immunoglobulin M and G levels after vaccination were higher in the group that exercised regularly than in the sedentary group. We were also able to demonstrate a significant correlation between levels of natural autoantibodies and response to vaccination.

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身体活跃的老年人对流感病毒疫苗应答中自身抗体和特异性抗体的产生增加

免疫衰老与衰老有关，在免疫反应的许多变化中，据报道，对疫苗接种的反应减少，以及由自身抗体(即天然抗体)引起的自身免疫病例数量增加，据报道，其功能是防止感染和炎症。虽然免疫衰老是一个不可逆转的过程，但有规律的适度运动可以减轻免疫系统某些方面的衰退。因此，本研究的目的是调查身体活跃的老年人在接种流感病毒疫苗前和接种后30天的体液免疫反应。结果显示，接种疫苗后抗核抗体和血清免疫球蛋白M和G水平呈阳性的个体百分比，经常运动的组高于不运动的组。我们还能够证明天然自身抗体水平与疫苗接种反应之间存在显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Results in immunology

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