Role of Nrf2 and HO-1 in intervertebral disc degeneration.

IF 2.8 4区医学 Q3 CELL BIOLOGY

Connective Tissue Research Pub Date : 2022-11-01 Epub Date: 2022-06-23 DOI:10.1080/03008207.2022.2089565

Cang-Yu Zhang, Xu-Chang Hu, Guang-Zhi Zhang, Ming-Qiang Liu, Hai-Wei Chen, Xue-Wen Kang

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引用次数: 5

Abstract

Intervertebral disc degeneration (IDD) is a common age-related disease with clinical manifestations of lumbar and leg pain and limited mobility. The pathogenesis of IDD is mainly mediated by the death of intervertebral disc (IVD) cells and the imbalance of extracellular matrix (ECM) synthesis and degradation. Oxidative stress and inflammatory reactions are the important factors causing this pathological change. Therefore, the regulation of reactive oxygen species and production of inflammatory factors may be an effective strategy to delay the progression of IDD. In recent years, nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream regulated protein heme oxygenase-1 (HO-1) have received special attention due to their antioxidant, anti-inflammatory and anti-apoptotic protective effects. Recent studies have elucidated the important role of these two proteins in the treatment of IDD disease. However, Nrf2 and HO-1 have not been systematically reported in IDD-related diseases. Therefore, this review describes the biological characteristics of Nrf2 and HO-1, the relationship between Nrf2- and HO-1-regulated oxidative stress and the inflammatory response and IDD, and the progress in research on some extracts targeting Nrf2 and HO-1 to improve IDD. Understanding the role and mechanism of Nrf2 and HO-1 in IDD may provide novel ideas for the clinical treatment and development of Nrf2- and HO-1-targeted drugs.

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Nrf2和HO-1在椎间盘退变中的作用。

椎间盘退变(IDD)是一种常见的与年龄有关的疾病，临床表现为腰、腿疼痛和活动受限。IDD的发病机制主要由椎间盘(IVD)细胞死亡和细胞外基质(ECM)合成和降解失衡介导。氧化应激和炎症反应是引起这种病理改变的重要因素。因此，调节活性氧和炎症因子的产生可能是延缓IDD进展的有效策略。近年来，核因子红细胞2相关因子2 (Nrf2)及其下游调控蛋白血红素加氧酶-1 (HO-1)因其抗氧化、抗炎和抗凋亡的保护作用而受到特别关注。最近的研究已经阐明了这两种蛋白在IDD疾病治疗中的重要作用。然而，Nrf2和HO-1在idd相关疾病中尚未有系统的报道。因此，本文就Nrf2和HO-1的生物学特性、Nrf2和HO-1调控氧化应激与炎症反应和IDD的关系以及一些靶向Nrf2和HO-1改善IDD的提取物的研究进展进行综述。了解Nrf2和HO-1在IDD中的作用和机制，可能为Nrf2-和HO-1靶向药物的临床治疗和开发提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.