Postinfantile giant cell hepatitis: an etiological and prognostic perspective.

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-03-11 DOI:10.1155/2013/601290
Chhagan Bihari, Archana Rastogi, Shiv Kumar Sarin
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Abstract

Giant cell hepatitis is common manifestation in pediatric liver diseases, but quite uncommon in adults, only about 100 cases reported in the English literature in the last two decades. Data for the present review were identified by a structured PubMed/MEDLINE search from 1963 to December 2012, using keywords postinfantile giant cell hepatitis (PIGCH), adult giant cell hepatitis, and syncytial giant cell hepatitis in adults and liver. We report a case of postinfantile giant cell hepatitis along with the review related to the etiology and respective outcome, as the literature in the last 20 years suggests. This condition is probably due to idiosyncratic or cytopathic response of individual to various hepatocytic stimuli. It is purely a histomorphological diagnosis and does not establish the etiology. Autoimmune liver diseases are most common etiology, in around 40% of cases, but various viruses, drugs, posttransplant condition, and other causes also have been reported. Prognosis depends upon the etiology. In this paper, we emphasized various causative factors of PIGCH and their respective outcome in patients affected by them. We also highlighted the possible pathogenesis and histopathological spectrum of this entity on the basis of description given in various studies and our limited experience of few cases.

Abstract Image

婴儿期后巨细胞肝炎:病因和预后的视角。
巨细胞性肝炎是儿科肝病的常见表现,但在成人中却非常罕见,过去二十年来,英文文献中仅报道了约 100 例。本综述的数据来源于1963年至2012年12月在PubMed/MEDLINE上进行的结构化检索,检索时使用了婴幼儿后巨细胞性肝炎(PIGCH)、成人巨细胞性肝炎、成人合胞巨细胞性肝炎和肝脏等关键词。我们报告了一例婴儿期后巨细胞性肝炎病例,并根据过去 20 年的文献回顾了其病因和相关结果。这种情况可能是由于个体对各种肝细胞刺激的特异性或细胞病理反应所致。这纯粹是一种组织形态学诊断,并不能确定病因。自身免疫性肝病是最常见的病因,约占病例总数的 40%,但也有报道称病因包括各种病毒、药物、移植后状况和其他原因。预后取决于病因。在本文中,我们强调了 PIGCH 的各种致病因素及其对患者的影响。我们还根据各种研究的描述和我们对少数病例的有限经验,强调了这种疾病可能的发病机制和组织病理学特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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