Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.

Tao Guo, Min Xuan, Cheng Zhou, Jingjing Wu, Ting Gao, Xueqin Bai, Xiaocao Liu, Luyan Gu, Ruiqi Liu, Zhe Song, Quanquan Gu, Peiyu Huang, Jiali Pu, Baorong Zhang, Xiaojun Xu, Xiaojun Guan, Minming Zhang
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引用次数: 2

Abstract

Hierarchical brain organization, in which the rich club and diverse club situate in core position, is critical for global information integration in the human brain network. Parkinson's disease (PD), a common movement disorder, has been conceptualized as a network disorder. Levodopa is an effective treatment for PD. Whether there is a functional divergence in the hierarchical brain system under PD pathology, and how this divergence is regulated by immediate levodopa therapy, remains unknown. We constructed a functional network in 61 PD patients and 89 normal controls and applied graph theoretical analyses to examine the neural mechanism of levodopa short response from the perspective of brain hierarchical configuration. The results revealed the following: (a) PD patients exhibited disrupted function within rich-club organization, while the diverse club preserved function, indicating a differentiated brain topological organization in PD. (b) Along the rich-club derivate hierarchical system, PD patients showed impaired network properties within rich-club and feeder subnetworks, and decreased nodal degree centrality in rich-club and feeder nodes, along with increased nodal degree in peripheral nodes, suggesting distinct functional patterns in different types of nodes. And (c) levodopa could normalize the abnormal network architecture of the rich-club system. This study provides evidence for levodopa effects on the hierarchical brain system with divergent functions.

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左旋多巴对帕金森病分层脑功能的正常化作用。
以丰富的俱乐部和多样化的俱乐部为核心的分层大脑组织是实现人脑网络全球信息整合的关键。帕金森病(PD)是一种常见的运动障碍,已被概念化为一种网络障碍。左旋多巴是治疗帕金森病的有效药物。PD病理下的等级脑系统是否存在功能分化,以及这种分化如何通过左旋多巴治疗进行调节,目前尚不清楚。我们构建了61例PD患者和89例正常对照的功能网络,并应用图论分析从脑层次结构的角度探讨左旋多巴短反应的神经机制。结果表明:(a) PD患者在富俱乐部组织中表现为功能破坏,而在多样化俱乐部组织中表现为功能保留,表明PD患者脑拓扑组织存在分化。(b)在rich-club衍生层级系统中,PD患者在rich-club和馈线子网络中表现出网络特性受损,rich-club和馈线节点的节点度中心性降低,外围节点的节点度增加,提示不同类型节点的功能模式不同。(c)左旋多巴可以使富国俱乐部系统的异常网络结构正常化。本研究为左旋多巴对具有不同功能的等级脑系统的影响提供了证据。
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