Core-shell alum-borneol fiber for high bioavailability.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2022-09-01 Epub Date: 2022-06-22 DOI:10.1007/s40204-022-00192-9
Yarong Lv, Yufen Han, Zhongxun Yu, Jia Chen, Chenxi Li, Ce Wang, Ping Hu, Yong Liu
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引用次数: 1

Abstract

Currently, the treatment of burns poses a significant challenge to clinical surgical. The use of nanofibers combined with drugs provides an entirely new option for treating burns. Alum-borneol combination has been shown as a promising alternative in clinical burn treatment. However, the utilization of the alum-borneol combination is not optimistic due to the low solubility of borneol. In this study, alum-borneol incorporated polyvinyl pyrrolidone fibers with a core-shell structure were fabricated through coaxial electrospinning. In vitro Borneol release behavior of fibers with different ratios of alum to borneol was explored. Scanning electron microscopy, transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimeter, in vitro drug release, and in vitro release mechanism were evaluated. The results showed that the fiber membranes maintained an integrated morphology. In vitro dissolution data showed an improved solubility of borneol, which reached more than 82% at 240 min in alum-borneol fibers. It was 4.8 times higher than borneol powder, and the ratio of alum to borneol was 2:1 for the best results. Therefore, alum-borneol incorporated polyvinyl pyrrolidone fibers can significantly improve the dissolution rate of borneol, which opens up a new way for the combined application of the alum and borneol.

高生物利用度的核壳铝冰片纤维。
目前,烧伤的治疗是临床外科面临的一个重大挑战。纳米纤维与药物的结合使用为治疗烧伤提供了一种全新的选择。铝冰片复合已被证明是临床烧伤治疗的一种很有前途的选择。然而,由于冰片溶解度低,铝-冰片组合的利用前景不容乐观。本研究采用同轴静电纺丝法制备了铝冰片复合聚乙烯吡咯烷酮芯壳结构纤维。考察了明矾与冰片不同配比纤维对冰片的体外释放行为。通过扫描电镜、透射电镜、傅里叶变换红外光谱、x射线衍射、差示扫描量热仪、体外释药及释药机制评价。结果表明,纤维膜保持完整的形态。体外溶出数据表明,冰片在铝冰片纤维中的溶解度提高,在240 min时溶解度达到82%以上。其含量是冰片粉的4.8倍,明矾与冰片的比例为2:1,效果最佳。因此,铝冰片掺入聚乙烯吡咯烷酮纤维可显著提高冰片的溶出率,为明矾与冰片的联合应用开辟了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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