LINC01088 regulates the miR-95/LATS2 pathway through the ceRNA mechanism to inhibit the growth, invasion and migration of gastric cancer cells.

IF 3 3区医学 Q3 IMMUNOLOGY

International Journal of Immunopathology and Pharmacology Pub Date : 2022-01-01 DOI:10.1177/03946320221108271

Zhuan Wen, Yong Li, Bibo Tan, Zihao Chen, Qun Zhao, Ming Tan, Yijie Zhao, Yuxiang Xia, Liqiao FanΔ

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Abstract

Background: In gastric cancer, a malignant condition with a dismal prognosis, long non-coding RNAs (LncRNAs) play a significant regulatory role. They often compete with microRNAs through the ceRNA mechanism to affect the expression of target mRNA. However, the specific clinical value and mechanism of action of LncRNA in gastric cancer are still unclear. Methods: This study detected the expression and clinical value of LINC01088 in gastric cancer tissues. Furthermore, the biological functions of LINC01088 and the regulation mechanism of the miR-95/LATS2 pathway were explored.Results: LINC01088 and LATS2 mRNA expression decreased, and miR-95 increased in gastric cancer tissues. LINC01088 has an excellent positive correlation with LATS2 mRNA, which may be a ceRNA pair; LINC01088 has binding sites with miR-95. Gene interference tests on gastric cancer cell lines revealed that LINC01088 could prevent gastric cancer cells from proliferating, invading, and migrating. The function of LINC01088 is achieved by regulating the miR-95/LATS2 pathway through the ceRNA mechanism.Conclusion: The results of this study show that LINC01088 expression is significantly reduced in gastric cancer tissues and cell lines. LINC01088 inhibits gastric cancer cells' proliferation, invasion, and migration by regulating the miR-95/LATS2 pathway via the ceRNA mechanism.

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LINC01088通过ceRNA机制调控miR-95/LATS2通路，抑制胃癌细胞的生长、侵袭和迁移。

背景:在胃癌这种预后不佳的恶性疾病中，长链非编码rna (LncRNAs)发挥着重要的调控作用。它们经常通过ceRNA机制与microrna竞争，影响靶mRNA的表达。然而，LncRNA在胃癌中的具体临床价值和作用机制尚不清楚。方法:本研究检测胃癌组织中LINC01088的表达及临床价值。进一步探讨LINC01088的生物学功能及miR-95/LATS2通路的调控机制。结果:胃癌组织中LINC01088、LATS2 mRNA表达降低，miR-95表达升高。LINC01088与LATS2 mRNA有极好的正相关，可能是ceRNA对;LINC01088与miR-95有结合位点。对胃癌细胞系的基因干扰实验表明，LINC01088能够抑制胃癌细胞的增殖、侵袭和迁移。LINC01088的功能是通过ceRNA机制调控miR-95/LATS2通路实现的。结论:本研究结果显示，胃癌组织和细胞系中LINC01088的表达明显降低。LINC01088通过ceRNA机制调节miR-95/LATS2通路，抑制胃癌细胞的增殖、侵袭和迁移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Immunopathology and Pharmacology 医学-病理学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.