Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential.

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-12-06 DOI:10.1155/2011/207326
Tom J Burdon, Arghya Paul, Nicolas Noiseux, Satya Prakash, Dominique Shum-Tim
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引用次数: 137

Abstract

During the past several years, there has been intense research in the field of bone marrow-derived stem cell (BMSC) therapy to facilitate its translation into clinical setting. Although a lot has been accomplished, plenty of challenges lie ahead. Furthermore, there is a growing body of evidence showing that administration of BMSC-derived conditioned media (BMSC-CM) can recapitulate the beneficial effects observed after stem cell therapy. BMSCs produce a wide range of cytokines and chemokines that have, until now, shown extensive therapeutic potential. These paracrine mechanisms could be as diverse as stimulating receptor-mediated survival pathways, inducing stem cell homing and differentiation or regulating the anti-inflammatory effects in wounded areas. The current review reflects the rapid shift of interest from BMSC to BMSC-CM to alleviate many logistical and technical issues regarding cell therapy and evaluates its future potential as an effective regenerative therapy.

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骨髓干细胞衍生的旁分泌因子用于再生医学:目前的观点和治疗潜力。
在过去的几年里,人们对骨髓干细胞(BMSC)治疗领域进行了大量的研究,以促进其在临床中的应用。尽管已经取得了很多成就,但前方仍有许多挑战。此外,越来越多的证据表明,骨髓间充质干细胞衍生的条件培养基(BMSC-CM)可以重现干细胞治疗后观察到的有益效果。骨髓间充质干细胞产生多种细胞因子和趋化因子,迄今为止已显示出广泛的治疗潜力。这些旁分泌机制可能是多种多样的,如刺激受体介导的生存途径,诱导干细胞归巢和分化,或调节损伤区域的抗炎作用。目前的综述反映了从骨髓间充质干细胞到骨髓间充质干细胞- cm的兴趣的快速转变,以缓解有关细胞治疗的许多后勤和技术问题,并评估其作为有效再生治疗的未来潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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