Hyperbaric oxygen therapy as a sole agent is not immunosuppressant in a highly immunogenic mouse model.

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2010-08-03 DOI:10.1155/2011/579268
Adam Gassas, Weixian Min, A Wayne Evans, Susan Carter, George K Sándor, Eyal Grunebaum
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引用次数: 1

Abstract

Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated skin graft rejection. Methods. C57/BL6 black-coated (H2B) mice received skin graft from CBA (H2D) white-coated mice. Mice were treated with either 19 session of 240 kpa oxygen or 29 session of 300 kpa oxygen, for 90 minutes. Mice were housed either 4 per cage or separately, to prevent friction and mechanical factors that may affect graft survival. Skin grafts were assessed daily. Results. There was no difference in length of graft survival between mice that received either regimens of HBO therapy and mice that did not receive HBO therapy. Conclusions. HBO therapy, as a sole agent, did not delay skin graft rejection in a highly immunogenic mouse model.

在高度免疫原性小鼠模型中,高压氧治疗作为单一药物不具有免疫抑制作用。
背景。高压氧(HBO)治疗用于许多情况,也可能具有免疫抑制作用,可用于预防或治疗移植物抗宿主病(GvHD)。如果HBO是免疫抑制剂,那么我们假设HBO治疗将延迟t细胞介导的皮肤移植排斥反应。方法。C57/BL6黑涂(H2B)小鼠接受CBA (H2D)白涂小鼠皮肤移植。小鼠分别接受19次240千帕或29次300千帕的氧气治疗,持续90分钟。每笼4只或单独饲养小鼠,以防止可能影响移植物存活的摩擦和机械因素。每天评估皮肤移植情况。结果。在接受HBO治疗的小鼠和未接受HBO治疗的小鼠之间,移植物存活的长度没有差异。结论。在高度免疫原性小鼠模型中,HBO治疗作为唯一的药物并没有延迟皮肤移植的排斥反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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