Long-term monitoring of age-related macular degeneration with preferential hyperacuity perimetry.

Ophthalmic Surgery Lasers & Imaging Pub Date : 2010-11-01 Epub Date: 2010-08-30 DOI:10.3928/15428877-20100830-05

Michael Stur, Yair Manor

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引用次数: 6

Abstract

Background and objective: To estimate the efficacy and usability of preferential hyper-acuity perimetry (PHP) for monitoring patients with high-risk intermediate age-related macular degeneration (AMD).

Patients and methods: A long-term, observational, prospective case series of patients with intermediate AMD who underwent fluorescein angiography at recruitment. Eyes were examined every 3 months with PHP, visual acuity, and biomicroscopy. Optical coherence tomography (OCT) imaging was performed when PHP was outside normal limits. In case of suspected findings in OCT, fluorescein angiography was also performed. Patients diagnosed as having choroidal neovascularization (CNV) were offered anti-vascular endothelial growth factor therapy.

Results: Twenty-six eyes (25 patients) were monitored for a mean follow-up period of 600 days. Of the 172 PHP tests done by these 26 eyes with intermediate AMD, 158 were within normal limits yielding a false-positive rate of 8.1%. Three of 4 eyes that converted to CNV had PHP test results outside normal limits before or on the day of diagnosis.

Conclusion: PHP is useful for detecting CNV in regularly monitored eyes with intermediate AMD while maintaining a low false-positive rate.

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使用优先的高敏度验光法长期监测老年性黄斑变性。

背景与目的:评价优先超视距检查(PHP)监测高危中度年龄相关性黄斑变性(AMD)患者的有效性和可用性。患者和方法:在招募时接受荧光素血管造影的中度AMD患者的长期、观察性、前瞻性病例系列。每3个月检查一次眼睛，包括PHP、视力和生物显微镜。当PHP超出正常范围时进行光学相干断层扫描(OCT)成像。在疑似OCT发现的情况下，也进行荧光素血管造影。诊断为脉络膜新生血管(CNV)的患者给予抗血管内皮生长因子治疗。结果:监测26只眼(25例)，平均随访600天。在这26只患有中度AMD的眼睛进行的172次PHP检查中，158次在正常范围内，假阳性率为8.1%。转化为CNV的4只眼睛中有3只在诊断前或当天的PHP检测结果超出正常范围。结论:PHP可用于常规监测的中度黄斑变性眼的CNV检测，且假阳性率低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Surgery Lasers & Imaging 医学-外科

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Surgery, Lasers and Imaging, an official publication of ARVO/ISIE, provides clinically valuable, practical articles in the field of ophthalmology on a bimonthly basis. The Journal publishes original, peer-reviewed articles that delve into the entire spectrum of ophthalmic surgery and treatment, including experimental science, surgical techniques, and video surgical clips. Subscribers can also benefit from our featured On Line Advanced Release—read articles before they appear in the print issue!