Target: ligand interactions of the vascular endothelium. Implications for molecular imaging in inflammation.

IF 1.4
Rohan S Wijesurendra, Andrew Jefferson, Robin P Choudhury
{"title":"Target: ligand interactions of the vascular endothelium. Implications for molecular imaging in inflammation.","authors":"Rohan S Wijesurendra,&nbsp;Andrew Jefferson,&nbsp;Robin P Choudhury","doi":"10.1039/c0ib00022a","DOIUrl":null,"url":null,"abstract":"<p><p>Molecular imaging refers to the non-invasive visualisation of biological processes at the molecular and cellular levels within a living organism, and offers a wide range of potential benefits to both clinical medicine and research into novel therapeutic agents. Inflammation plays an important role in a wide variety of pathological processes and imaging the molecular and cellular machinery that underlies chronic inflammation is attractive and feasible. In this review, we present an overview of molecular imaging of inflammation. We start by characterising molecular and cellular events in early inflammation, identifying current and potential future imaging targets. We focus on the imaging of endothelial cells, which mediate the important first steps in inflammation in any tissue, are readily accessible to imaging probes and which present an approach that can be applied across multiple modalities. We then review the generic requirements for imaging contrast agents and focus on the important considerations in respect of ligands, ligand-target interactions and contrast vehicles. We aim to provide an integrated view of current progress with a focus on promising recent developments in experimental and translational molecular imaging.</p>","PeriodicalId":520649,"journal":{"name":"Integrative biology : quantitative biosciences from nano to macro","volume":" ","pages":"467-82"},"PeriodicalIF":1.4000,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/c0ib00022a","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative biology : quantitative biosciences from nano to macro","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1039/c0ib00022a","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2010/9/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

Molecular imaging refers to the non-invasive visualisation of biological processes at the molecular and cellular levels within a living organism, and offers a wide range of potential benefits to both clinical medicine and research into novel therapeutic agents. Inflammation plays an important role in a wide variety of pathological processes and imaging the molecular and cellular machinery that underlies chronic inflammation is attractive and feasible. In this review, we present an overview of molecular imaging of inflammation. We start by characterising molecular and cellular events in early inflammation, identifying current and potential future imaging targets. We focus on the imaging of endothelial cells, which mediate the important first steps in inflammation in any tissue, are readily accessible to imaging probes and which present an approach that can be applied across multiple modalities. We then review the generic requirements for imaging contrast agents and focus on the important considerations in respect of ligands, ligand-target interactions and contrast vehicles. We aim to provide an integrated view of current progress with a focus on promising recent developments in experimental and translational molecular imaging.

目标:血管内皮的配体相互作用。炎症分子成像的意义。
分子成像是指在生物体内的分子和细胞水平上对生物过程进行非侵入性可视化,并为临床医学和新型治疗药物的研究提供了广泛的潜在益处。炎症在多种病理过程中发挥着重要作用,慢性炎症的分子和细胞机制成像是有吸引力和可行的。在这篇综述中,我们介绍了炎症分子成像的概述。我们首先描述早期炎症的分子和细胞事件,确定当前和潜在的未来成像目标。我们专注于内皮细胞的成像,它介导了任何组织炎症的重要第一步,很容易被成像探针接近,并且提供了一种可以应用于多种模式的方法。然后,我们回顾了成像造影剂的一般要求,并重点介绍了配体、配体-靶相互作用和造影剂方面的重要考虑因素。我们的目标是提供一个综合的观点,目前的进展,重点是有希望的最新发展,在实验和转化分子成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信