Future research trends in the major chemical language of bacteria.

Abstract

Microbiology was revolutionized in the 1990's by the discovery that many different bacterial species coordinate their behavior when they form a group. In fact, bacteria are now considered multicellular organisms capable of communicating and changing behavior in relation to their cell-density; since 1994 this has been called quorum sensing. This group behavior ensures survival and propagation of the community in many natural environments. Bacterial intercellular communication is mediated by different chemical signals that are synthesized by bacteria which are then either secreted or diffused in the external environment. Bacteria are then able to detect the type and concentration of the signal resulting in regulation of gene expression and, consequently, a synchronized response by the community. The predominant signalling molecules produced by Gram-negative bacteria are N-acyl derivatives of homoserine lactone (AHLs) which have been shown to be produced by over seventy bacterial species. In this essay we discuss the importance of quorum sensing via AHLs and highlight current and future trends in this important field of research.