Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy.

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2008-02-27 DOI:10.2174/1874104500802010006

Anna Blázovics, Agnes Szilvás, György Székely, Eniko Tordai, Edit Székely, Gábor Czabai, Zsolt Pallai, Eva Sárdi

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引用次数: 14

Abstract

Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer.

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结直肠癌患者结肠切除术后红细胞的重要生物活性分子。

甲醛(HCHO)和原卟啉与氧化还原稳态有关。数据显示HCHO在增殖和凋亡过程中的重要性。游离原卟啉可以在癌组织中zn -原卟啉附近检测到，根据浓度的不同，它有原卟啉和抗氧化形式。目的是测定结直肠癌结肠切除术后红细胞中HCHO的含量和原卟啉浓度，并估计氧化还原稳态。本研究共纳入32例结肠切除术后5-10年的成年患者和9名健康志愿者。检测肿瘤标志物、氧化还原参数、HbA1c、HCHO和原卟啉浓度。结肠切除术患者的红细胞HCHO明显低于对照组。原卟啉在患者中浓度较低，但在转移灶中浓度显著。HbA1c与自由基显著相关，降低红细胞抗氧化能力。红细胞HCHO、原卟啉浓度和总清除率是肿瘤的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

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