Peritoneal Dialysis Preserves Residual Renal Function and Reduces Oxidative Stress During the Initial Period of Dialysis Therapy.

Abstract

Patients with end-stage renal failure are believed to have an increase of oxidative stress. However, any variation in oxidative stress between patients receiving hemodialysis (HD) and those receiving peritoneal dialysis (PD) are still unclear. In the present study, we investigated variation in oxidative stress in 54 HD and 23 PD patients during their initial dialysis period.We measured serum pentosidine and indoxylsulfuric acid as markers of oxidative stress every 6 months from the start of the dialysis therapy to 30 months of treatment. Serum pentosidine was significantly lower in the PD patients than in the HD patients. Serum indoxylsulfuric acid was also significantly lower in the PD group compared with the HD group at 6, 12, and 18 months. Compared with the HD patients, the PD patients maintained significantly higher urine volumes (a marker of residual renal function) throughout the study, except at 24 months.Our findings demonstrate that, compared with HD patients, PD patients experience lower levels of oxidative stress because of higher preserved residual renal function during the initial dialysis period.