The annoying flaws of gerontological research.

Abstract

Gerontological research has accelerated dramatically in the last few decades. However, despite increased public interest, federal funding, an army of researchers, and many notable discoveries and high-impact publications, the goal of achieving even a modest extension of human lifespan seems to be as far away as ever or, at best, remains within the realm of lifestyle and diet optimization efforts. Humanity has already benefited from a lifespan revolution in the first half of the 20th Century, which was brought about by improved sanitation and hygiene, clean water, and our successful war on infectious diseases. Thanks to all these developments, in which gerontologists played no part, our expected lifespan increased by about 40% and our primary causes of death decidedly shifted from extrinsic to intrinsic causality. The next step is not that simple as it implies tackling intrinsic mechanisms of aging, and the lack of working human-specific antiaging solutions likely stems from flawed research strategies.