Non-organ confined stage and upgrading rates in exclusive PSA high-risk prostate cancer patients.

The Prostate Pub Date : 2022-05-01 Epub Date: 2022-02-21 DOI:10.1002/pros.24313
Benedikt Hoeh, Rocco S Flammia, Lukas Hohenhorst, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F Shariat, Markus Graefen, Derya Tilki, Luis A Kluth, Philipp Mandel, Andreas Becker, Felix K H Chun, Pierre I Karakiewicz
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引用次数: 3

Abstract

The pathological stage of prostate cancer with high‐risk prostate‐specific antigen (PSA) levels, but otherwise favorable and/or intermediate risk characteristics (clinical T‐stage, Gleason Grade group at biopsy [B‐GGG]) is unknown. We hypothesized that a considerable proportion of such patients will exhibit clinically meaningful GGG upgrading or non‐organ confined (NOC) stage at radical prostatectomy (RP).
特异性PSA高危前列腺癌患者的非器官局限期和升级率。
背景:具有高危前列腺特异性抗原(PSA)水平,但其他有利和/或中等危险特征(临床t期,活检Gleason分级组[B-GGG])的前列腺癌的病理分期尚不清楚。我们假设相当大比例的此类患者在根治性前列腺切除术(RP)中将表现出具有临床意义的GGG升级或非器官受限(NOC)阶段。材料和方法:在监测、流行病学和最终结果数据库(2010-2015)中,我们确定了ct1c期和B-GGG1、B-GGG2或B-GGG3的rp患者,PSA为20-50 ng/ml。分析GGG4或GGG5的比率和/或NOC分期(≥pT3和/或pN1)的比率。随后,单独的单变量和多变量逻辑回归模型测试了RP NOC阶段和升级的预测因子。结果:在486例可评估患者中,134例(28%)表现为B-GGG1, 209例(43%)表现为B-GGG2, 143例(29%)表现为B-GGG3。总体升级和NOC率分别为11%和51%,升级和/或NOC阶段的综合比率为53%。在预测升级的多变量logistic回归模型中,只有B-GGG3是独立预测因子(比值比[OR]: 5.29;95%置信区间[CI]: 2.21-14.19;66%阳性活检芯(OR: 4.85;95% ci: 2.84-8.42;结论:在基线有高危PSA但低至中危B-GGG的ct1c期患者中,升级到GGG4或GGG5的比率很低(11%)。然而,NOC分期在大多数(51%)中被发现,并且可以通过活检和B-GGG阳性芯的百分比独立预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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