Impact of prediabetes and duration of diabetes on radial artery atherosclerosis in acute coronary syndrome patients: An optical coherence tomography study.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2022-01-01 DOI:10.1177/14791641221078108

Zixuan Li, Zhe Tang, Yujie Wang, Zijing Liu, Senhu Wang, Yuntao Wang, Guozhong Wang, Yuping Wang, Jincheng Guo

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引用次数: 0

Abstract

Background: Prediabetes (PDM) and diabetes mellitus (DM) are common among acute coronary syndrome (ACS) patients. The present study evaluated the association between diabetes status and radial artery (RA) atherosclerosis using optical coherence tomography (OCT) in ACS patients.

Methods: A total of 335 ACS patients who underwent RA OCT were categorized into the DM group, the PDM group, and the normal glucose metabolism (NGM) group. OCT characteristics and clinical variables were compared.

Results: RA atherosclerotic plaques were more frequent in the PDM and DM groups than in the NGM group (38.7% vs. 33.3% vs. 16.1%, p = 0.001). Lipid and calcified plaque occurrence were significantly more common in the DM group, followed by the PDM and NGM groups (19.3% vs. 14.6% vs. 6.5%, p = 0.027; 11.8% vs. 6.5% vs. 1.1%, p = 0.009). The prevalence of microvessels in the PDM group was significantly higher (42.7% vs 23.7%, p = 0.017) than in the NGM group but was comparable to the DM group. Multivariate analysis revealed that HbA1c level and age were independent predictors of RA plaque formation and eccentric intimal hyperplasia (all p<0.05).

Conclusions: RA atherosclerosis characteristics differ according to diabetes status. HbA1c level could be a useful marker for RA atherosclerosis progression in ACS patients.

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糖尿病前期和糖尿病病程对急性冠状动脉综合征患者桡动脉粥样硬化的影响:一项光学相干断层扫描研究

背景:前驱糖尿病(PDM)和糖尿病(DM)在急性冠脉综合征(ACS)患者中很常见。本研究利用光学相干断层扫描(OCT)评估ACS患者的糖尿病状态与桡动脉粥样硬化之间的关系。方法:335例ACS患者行RA OCT分为DM组、PDM组和正常糖代谢组。比较OCT特征和临床指标。结果:PDM组和DM组RA动脉粥样硬化斑块发生率高于NGM组(38.7% vs. 33.3% vs. 16.1%， p = 0.001)。脂质斑块和钙化斑块在DM组更为常见，其次是PDM组和NGM组(19.3% vs. 14.6% vs. 6.5%， p = 0.027;11.8%比6.5%比1.1%，p = 0.009)。PDM组微血管患病率显著高于NGM组(42.7% vs 23.7%， p = 0.017)，但与DM组相当。多因素分析显示，HbA1c水平和年龄是RA斑块形成和偏心内膜增生的独立预测因素。结论:RA动脉粥样硬化特征因糖尿病状态而异。HbA1c水平可能是ACS患者RA动脉粥样硬化进展的有用标志。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)