Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-02-17 DOI:10.1049/syb2.12040

Yandong Miao, Bin Su, Xiaolong Tang, Jiangtao Wang, Wuxia Quan, Yonggang Chen, Denghai Mi

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引用次数: 1

Abstract

N6-methyladenosine (m⁶A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m⁶A RNA methylation regulators. This paper aimed to explore 13 m⁶A RNA methylation regulators' role in gastrointestinal cancer (GIC) and determine the risk model and prognosis value of m⁶A RNA methylation regulators in GIC. We used several bioinformatics methods to identify the differential expression of m⁶A RNA methylation regulators in GIC, constructed a prognostic model, and carried out functional enrichment analysis. Eleven of 13 m⁶A RNA methylation regulators were differentially expressed in different clinicopathological characteristics of GIC, and m⁶A RNA methylation regulators were nearly associated with GIC. We constructed a risk model based on five m⁶A RNA methylation regulators (METTL3, FTO, YTHDF1, ZC3H13, and WTAP); the risk score is an independent prognosis biomarker. Moreover, the five m⁶A RNA methylation regulators can also forecast the 1-, 3- and 5-year overall survival through a nomogram. Furthermore, four hallmarks of oxidative phosphorylation, glycolysis, fatty acid metabolism, and cholesterol homoeostasis gene sets were significantly enriched in GIC. m⁶A RNA methylation regulators were related to the malignant clinicopathological characteristics of GIC and may be used for prognostic stratification and development of therapeutic strategies.

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m6A RNA甲基化调控因子相关胃肠道肿瘤预后模型的构建与验证

n6 -甲基腺苷(m6A) RNA甲基化与癌症发生相关，并通过m6A RNA甲基化调控因子动态实现。本文旨在探讨13种m6A RNA甲基化调节剂在胃肠道癌(GIC)中的作用，确定m6A RNA甲基化调节剂在GIC中的风险模型和预后价值。我们使用多种生物信息学方法鉴定了m6A RNA甲基化调控因子在GIC中的差异表达，构建了预后模型，并进行了功能富集分析。13个m6A RNA甲基化调节因子中有11个在GIC的不同临床病理特征中存在差异表达，m6A RNA甲基化调节因子与GIC几乎相关。我们基于5个m6A RNA甲基化调节因子(METTL3、FTO、YTHDF1、ZC3H13和WTAP)构建了风险模型;风险评分是一个独立的预后生物标志物。此外，5种m6A RNA甲基化调节因子也可以通过nomogram预测1、3和5年的总生存率。此外，氧化磷酸化、糖酵解、脂肪酸代谢和胆固醇同质平衡基因组在GIC中显著富集。m6A RNA甲基化调节因子与GIC的恶性临床病理特征有关，可用于预后分层和治疗策略的制定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.