A HALP score-based prediction model for survival of patients with the upper tract urothelial carcinoma undergoing radical nephroureterectomy.

IF 3.4 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Xiaomin Gao, Binwei Lin, Qi Lin, Tingyu Ye, Tao Zhou, Maolin Hu, Honghui Zhu, Feng Lu, Wei Chen, Peng Xia, Fangyi Zhang, Zhixian Yu
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引用次数: 5

Abstract

The combination of hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as an important risk biomarker in several cancers. Hence, we aimed at evaluating the prognostic value of the HALP score in patients with non-metastatic upper tract urothelial carcinoma (UTUC). We retrospectively enrolled 533 of the 640 patients from two centers (315 and 325 patients, respectively) who underwent radical nephroureterectomy (RNU) for UTUC in this study. The cutoff value of HALP was determined using the Youden index by performing receiver operating characteristic (ROC) curve analysis. The relationship between postoperative survival outcomes and preoperative HALP level was assessed using Kaplan-Meier analysis and Cox regression analysis. As a result, the cutoff value of HALP was 28.67 and patients were then divided into HALP<28.67 group and HALP≥28.67 group. Kaplan-Meier analysis and log-rank test revealed that HALP was significantly associated with overall survival (OS) (P<0.001) and progression-free survival (PFS) (P<0.001). Multivariate analysis demonstrated that lower HALP score was an independent risk factor for OS (HR=1.54, 95%CI, 1.14-2.01, P=0.006) and PFS (HR=1.44, 95%CI, 1.07-1.93, P=0.020). Nomograms of OS and PFS incorporated with HALP score were more accurate in predicting prognosis than without. In the subgroup analysis, the HALP score could also stratify patients with respect to survival under different pathologic T stages. Therefore, pretreatment HALP score was an independent prognostic factor of OS and PFS in UTUC patients undergoing RNU.

Abstract Image

Abstract Image

Abstract Image

基于HALP评分的上尿路上皮癌行根治性肾输尿管切除术患者生存预测模型。
血红蛋白、白蛋白、淋巴细胞和血小板(HALP)联合评分已被证实是几种癌症的重要风险生物标志物。因此,我们旨在评估HALP评分在非转移性上尿路上皮癌(UTUC)患者中的预后价值。在本研究中,我们回顾性地纳入了来自两个中心的640例患者中的533例(分别为315例和325例),这些患者接受了根治性肾输尿管切除术(RNU)治疗UTUC。采用约登指数进行受试者工作特征(ROC)曲线分析,确定HALP的截止值。采用Kaplan-Meier分析和Cox回归分析评估术后生存结局与术前HALP水平的关系。因此,HALP的临界值为28.67,并将患者分为HALP组
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来源期刊
Bosnian journal of basic medical sciences
Bosnian journal of basic medical sciences 医学-医学:研究与实验
CiteScore
7.40
自引率
5.90%
发文量
98
审稿时长
35 days
期刊介绍: The Bosnian Journal of Basic Medical Sciences (BJBMS) is an international, English-language, peer reviewed journal, publishing original articles from different disciplines of basic medical sciences. BJBMS welcomes original research and comprehensive reviews as well as short research communications in the field of biochemistry, genetics, immunology, microbiology, pathology, pharmacology, pharmaceutical sciences and physiology.
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