Detection, dietary exposure assessment and risk evaluation of quinolones and pyrrolizidine alkaloids in commercial honey from Brazil.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED

Food additives & contaminants. Part B, Surveillance Pub Date : 2022-06-01 Epub Date: 2022-02-03 DOI:10.1080/19393210.2022.2028310

Thiago Bousquet Bandini, Bernardete Ferraz Spisso

引用次数: 2

Abstract

Pyrrolizidine alkaloids are secondary plant metabolites that have already been designated as a potential health risk due to their toxicity. Quinolones are antimicrobials related to bacterial resistance, one of the world's largest contemporary public health problems. This study searched for 22 pyrrolizidine alkaloids and 7 quinolones in honey available for sale in the state of Rio de Janeiro - Brazil - employing an analytical method based on LC-Q-TOF-HRMS. No quinolones were identified, while pyrrolizidine alkaloids were found in 39 out of 80 samples, mainly erucifoline (detected in 17% of the samples) and intermedine/lycopsamine (quantified in 27% of the samples). Considering the highest value found, 141.8 µg kg^-1 for senecionine and a consumption of 20 g of honey per person per day, the dietary exposure reached 47.3 ng kg^-1, resulting in a MOE value of 5.010, that might lead to a risk for human health.

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巴西商品蜂蜜中喹诺酮类和吡咯利西啶类生物碱的检测、膳食暴露评估和风险评估。

吡咯利西啶生物碱是次生植物代谢物，由于其毒性已被指定为潜在的健康风险。喹诺酮类药物是与细菌耐药性有关的抗微生物药物，细菌耐药性是当今世界最大的公共卫生问题之一。采用LC-Q-TOF-HRMS分析方法，对巴西里约热内卢市售蜂蜜中22种吡罗里西啶类生物碱和7种喹诺酮类药物进行了分析。80份样品中未检出喹诺酮类生物碱，39份样品中检出吡咯利西啶类生物碱，主要是绿弗林(检出率为17%)和中间体/番茄胺(检出率为27%)。考虑到所发现的最高值(141.8 μ g kg-1)和每人每天食用20 g蜂蜜，膳食暴露量达到47.3 ng kg-1，其MOE值为5.010，可能导致人体健康风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.