Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Pediatric Acute Respiratory Distress Syndrome.

IF 0.8 Q4 RESPIRATORY SYSTEM

Turkish Thoracic Journal Pub Date : 2021-07-01 DOI:10.5152/TurkThoracJ.2021.20087

Merve Mısırlıoğlu, Dinçer Yıldızdaş, Özden Özgür Horoz, Faruk Ekinci, Zeliha Haytoğlu, Nagehan Aslan

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引用次数: 2

Abstract

Objective: Acute respiratory distress syndrome (ARDS) is a clinical picture that indicates severe acute hypoxemic respiratory insufficiency. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are convenient, uncomplicated, and inexpensive parameters that can be used in detecting the severity of the disease. The prognostic role of NLR and PLR in patients with pediatric ARDS is unknown. The aim of this study was to investigate if there was any relationship between initial hematological parameters and the stages of ARDS, duration of mechanical ventilation and the length of intensive care stay in pediatric ARDS.

Material and methods: Of 34 patients diagnosed with ARDS, 5 excluded, a total of 29 patients who were followed in our pediatric intensive care unit between 2016 and 2018 were retrospectively enrolled. Patients were retrospectively registered in terms of demographical features, disease severity scores (PIM2, PRISM III, PELOD scores), lymphocyte, neutrophil and platelet counts and NLR, PLR values in complete blood count during intensive care unit stay and on the day of discharge, the stages of ARDS, duration of mechanical and the length of intensive care stay.

Results: There was a significant relationship between NLR values and ARDS stages on the first day of the admittance (P = .003). There was a moderate correlation between NLR and PELOD scores on the day of admittance and it was statistically significant (r = 0.45, P = .026). There was no correlation between mechanical ventilation time and the length of intensive care stay and NLR-PLR values. Platelet-to-lymphocyte ratio was not identified as a prognostic factor in our study.

Conclusion: In diagnosis of the severity of ARDS with severe acute hypoxemic respiratory insufficiency, NLR is a convenient and inexpensive parameter that can only be calculated by complete blood count.

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小儿急性呼吸窘迫综合征的中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率。

目的:急性呼吸窘迫综合征(Acute respiratory distress syndrome, ARDS)是一种严重急性低氧性呼吸功能不全的临床表现。中性粒细胞与淋巴细胞比率(NLR)和血小板与淋巴细胞比率(PLR)是方便、简单、廉价的参数，可用于检测疾病的严重程度。NLR和PLR在儿童ARDS患者预后中的作用尚不清楚。本研究的目的是探讨小儿ARDS的初始血液学参数与ARDS的分期、机械通气时间和重症监护时间之间是否存在关系。材料和方法:回顾性纳入2016年至2018年在我们的儿科重症监护病房随访的34例ARDS患者，其中5例被排除。回顾性登记患者的人口学特征、疾病严重程度评分(PIM2、PRISM III、PELOD评分)、淋巴细胞、中性粒细胞和血小板计数以及重症监护室住院期间和出院当天全血细胞计数NLR、PLR值、ARDS分期、机械时间和重症监护时间。结果:NLR值与入院第一天ARDS分期有显著相关(P = 0.003)。入院当天NLR与PELOD评分有中度相关，差异有统计学意义(r = 0.45, P = 0.026)。机械通气时间与重症监护住院时间及NLR-PLR值无相关性。在我们的研究中，血小板与淋巴细胞的比例未被确定为预后因素。结论:在ARDS合并严重急性低氧性呼吸功能不全的严重程度诊断中，NLR是一种仅能通过全血细胞计数计算的方便、廉价的参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Thoracic Journal Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

11.10%

发文量

期刊介绍： Turkish Thoracic Journal (Turk Thorac J) is the double-blind, peer-reviewed, open access, international publication organ of Turkish Thoracic Society. The journal is a quarterly publication, published on January, April, July, and October and its publication language is English. Turkish Thoracic Journal started its publication life following the merger of two journals which were published under the titles “Turkish Respiratory Journal” and “Toraks Journal” until 2007. Archives of both journals were passed on to the Turkish Thoracic Journal. The aim of the journal is to convey scientific developments and to create a dynamic discussion platform about pulmonary diseases. With this intent, the journal accepts articles from all related scientific areas that address adult and pediatric pulmonary diseases, as well as thoracic imaging, environmental and occupational disorders, intensive care, sleep disorders and thoracic surgery. Clinical and research articles, reviews, statements of agreement or disagreement on controversial issues, national and international consensus reports, abstracts and comments of important international articles, interesting case reports, writings related to clinical and practical applications, letters to the editor, and editorials are accepted.