Investigation of Granulomatous Inflammations in Terms of Tuberculosis Diagnosis: A 5-Year Multi-center Laboratory Study.

IF 0.8 Q4 RESPIRATORY SYSTEM
Derya Öztomurcuk, Özlem Terzi, Canan Demirci, Zeki Kılıçaslan
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引用次数: 1

Abstract

Objective: Granulomatous inflammation showing "caseification necrosis" is considered pathognomonic for tuberculosis. This study aimed to evaluate patients with granulomatous inflammation and some characteristics to diagnose tuberculosis.

Material and methods: This is a cross-sectional descriptive study. The study includes all pathology laboratories in Samsun between the years 2012 and 2017. Pathology reports that contained the term granulomatous were selected between all patient reports of these laboratories. The patient reports were examined by comparing the dispensary records and the presence of a diagnosis of tuberculosis.

Results: In the 703 pathology reports, it was found that 38% were only granulomatous and 33% were caseous granulomatosis lesions. When the prevalence of tuberculosis according to the presence of microscopic necrosis was observed in granulomatous tissue samples, 85% tuberculosis was found in patients with necrotic granulomatous tissue and 14% tuberculosis was found with non-necrotic lesions. The presence of tuberculosis in necrotic granulomatous tissues was statistically significantly higher (P < .00001).

Conclusion: As a result, when examining a pathology report for the presence of tuberculosis, the existence of a granulomatous reaction should be considered first. Getting stuck on the definition of caseification necrosis will cause the case to be skipped. An indication of necrosis in the pathologic evaluation will guide the diagnosis of tuberculosis.

Abstract Image

Abstract Image

肉芽肿性炎症在结核病诊断中的研究:一项5年多中心实验室研究。
目的:肉芽肿性炎症表现为“干酪化坏死”被认为是结核病的典型症状。本研究旨在评估肉芽肿性炎症患者的一些特征,以诊断结核病。材料和方法:这是一项横断面描述性研究。该研究包括2012年至2017年三星电子所有病理实验室。病理报告中包含术语肉芽肿是从这些实验室的所有患者报告中选择的。通过比较药房记录和结核病诊断的存在来检查患者报告。结果:703份病理报告中,仅肉芽肿性病变占38%,干酪样肉芽肿性病变占33%。根据肉芽肿组织标本中有无镜下坏死来观察结核的患病率时,坏死性肉芽肿组织中结核的发生率为85%,非坏死性病变中结核的发生率为14%。坏死肉芽肿组织中结核的存在有统计学意义(P < 0.00001)。结论:因此,在检查结核的病理报告时,应首先考虑肉芽肿反应的存在。执着于干酪化坏死的定义会导致病例被跳过。病理评价中的坏死指征将指导肺结核的诊断。
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来源期刊
Turkish Thoracic Journal
Turkish Thoracic Journal Medicine-Pulmonary and Respiratory Medicine
CiteScore
1.40
自引率
11.10%
发文量
2
期刊介绍: Turkish Thoracic Journal (Turk Thorac J) is the double-blind, peer-reviewed, open access, international publication organ of Turkish Thoracic Society. The journal is a quarterly publication, published on January, April, July, and October and its publication language is English. Turkish Thoracic Journal started its publication life following the merger of two journals which were published under the titles “Turkish Respiratory Journal” and “Toraks Journal” until 2007. Archives of both journals were passed on to the Turkish Thoracic Journal. The aim of the journal is to convey scientific developments and to create a dynamic discussion platform about pulmonary diseases. With this intent, the journal accepts articles from all related scientific areas that address adult and pediatric pulmonary diseases, as well as thoracic imaging, environmental and occupational disorders, intensive care, sleep disorders and thoracic surgery. Clinical and research articles, reviews, statements of agreement or disagreement on controversial issues, national and international consensus reports, abstracts and comments of important international articles, interesting case reports, writings related to clinical and practical applications, letters to the editor, and editorials are accepted.
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