Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy.

IF 1.8 3区 医学 Q4 TOXICOLOGY
Lilian Caroline Gonçalves Oliveira, Nayara Azinheira Nobrega Cruz, Bruna Ricelli, Helio Tedesco-Silva, José Osmar Medina-Pestana, Dulce Elena Casarini
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引用次数: 2

Abstract

Coronavirus disease 2019 (COVID-19) is a rapid-spread infectious disease caused by the SARS-CoV-2 virus, which can culminate in the renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) systems imbalance, and in serious consequences for infected patients. This scoping review of published research exploring the RAAS and KKS was undertaken in order to trace the history of the discovery of both systems and their multiple interactions, discuss some aspects of the viral-cell interaction, including inflammation and the system imbalance triggered by SARS-CoV-2 infection, and their consequent disorders. Furthermore, we correlate the effects of continued use of the RAAS blockers in chronic diseases therapies with the virulence and physiopathology of COVID-19. We also approach the RAAS and KKS-related proposed potential therapies for treatment of COVID-19. In this way, we reinforce the importance of exploring both systems and the application of their components or their blockers in the treatment of coronavirus disease.

Abstract Image

Abstract Image

炎症、肾素-血管紧张素-醛固酮和钾化钾素-激肽系统之间的相互作用:COVID-19治疗的建议方法
2019冠状病毒病(COVID-19)是由SARS-CoV-2病毒引起的一种快速传播的传染病,其最终可导致肾素-血管紧张素-醛固酮(RAAS)和钾likrein- kinins (KKS)系统失衡,并对感染患者造成严重后果。本文对已发表的有关RAAS和KKS的研究进行了范围审查,以追溯这两个系统的发现历史及其多种相互作用,讨论病毒-细胞相互作用的某些方面,包括由SARS-CoV-2感染引发的炎症和系统失衡,以及随之而来的疾病。此外,我们将慢性疾病治疗中持续使用RAAS阻滞剂的效果与COVID-19的毒力和生理病理联系起来。我们还探讨了与RAAS和kks相关的潜在治疗方法。通过这种方式,我们强调了探索这两个系统及其成分或阻滞剂在治疗冠状病毒疾病中的应用的重要性。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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