Saliva Fatigue Biomarker Index As a Marker for Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community Based Sample.

IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Fatigue-Biomedicine Health and Behavior Pub Date : 2021-01-01 Epub Date: 2021-10-27 DOI:10.1080/21641846.2021.1994222

Leonard A Jason, John Kalns, Alicia Richarte, Ben Z Katz, Chelsea Torres

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引用次数: 1

Abstract

Objective: The prevalence of pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been estimated from an ethnically and sociodemographically diverse community-based random sample of 10,119 youth aged 5-17. A team of physicians made a final diagnosis of ME/CFS if the participants met criteria for up to three selected case definitions following medical and psychiatric evaluations. We assessed whether a salivary biomarker of fatigue could identify youth with ME/CFS.

Study design: We examined the ratio of the concentrations of 2 peptide fragments in saliva, referred to as the Fatigue Biomarker Index (FBI), in participants from our study diagnosed with ME/CFS (n=59) and matched controls (n=39).

Results: Significant overall differences were found in the FBI between those participants with severe ME/CFS and those with ME/CFS and the controls.

Conclusions: If confirmed in other populations, the FBI could serve as an objective test to aid in the diagnosis of severe ME/CFS.

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唾液疲劳生物标志物指数在社区样本中作为重度肌痛性脑脊髓炎/慢性疲劳综合征的标志物

目的:对10,119名5-17岁的儿童进行种族和社会人口统计学随机抽样，估计儿童肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)的患病率。如果参与者在医学和精神病学评估后符合最多三个选定病例定义的标准，一组医生就会做出ME/CFS的最终诊断。我们评估了疲劳的唾液生物标志物是否可以识别患有ME/CFS的年轻人。研究设计:我们在我们的研究中诊断为ME/CFS的参与者(n=59)和匹配的对照组(n=39)中检测了唾液中2种肽片段的浓度之比，即疲劳生物标志物指数(FBI)。结果:在严重ME/CFS患者与ME/CFS患者和对照组之间，FBI有显著的总体差异。结论:如果在其他人群中得到证实，FBI可以作为一种客观的测试来帮助诊断严重的ME/CFS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fatigue-Biomedicine Health and Behavior MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.20

自引率

7.10%

发文量

期刊介绍： Fatigue: Biomedicine, Health and Behavior is an international, interdisciplinary journal that addresses the symptom of fatigue in medical illnesses, behavioral disorders, and specific environmental conditions. These broadly conceived domains, all housed in one journal, are intended to advance research on causation, pathophysiology, assessment, and treatment. The list of topics covered in Fatigue will include fatigue in diseases including cancer, autoimmune diseases, multiple sclerosis, pain conditions, mood disorders, and circulatory diseases. The journal will also publish papers on chronic fatigue syndrome, fibromyalgia and related illnesses. In addition, submissions on specific issues involving fatigue in sleep, aging, exercise and sport, and occupations are welcomed. More generally, the journal will publish on the biology, physiology and psychosocial aspects of fatigue. The Editor also welcomes new topics such as clinical fatigue education in medical schools and public health policy with respect to fatigue.