Impact of General Factors on Glioma Immunotherapy.

Qilin Huang, Dongmei Wang, Guojie Yao, Hongxiang Wang
{"title":"Impact of General Factors on Glioma Immunotherapy.","authors":"Qilin Huang,&nbsp;Dongmei Wang,&nbsp;Guojie Yao,&nbsp;Hongxiang Wang","doi":"10.3988/jcn.2022.18.1.3","DOIUrl":null,"url":null,"abstract":"<p><p>Glioma remains the most common malignant tumor in the brain and is also the most difficult to treat. Immunotherapy achieving long-lasting tumor remission in multiple cancer types has received considerable attention due to its potential to improve the treatment outcomes of patients with glioma. However, clinical trials have not yet demonstrated major improvements in prognoses, which might be attributable to the extrinsic components and intrinsic mechanisms involved in the tumor microenvironment and immune system. It is particularly noteworthy that there is emerging evidence that current routine treatment modalities and the physical and psychological characteristics of patients have different impacts on the efficacy of glioma immunotherapy. This article addresses how these factors interact with the host immune system and tumor microenvironment, and highlights their potential roles in glioma immunotherapy, with the ultimate goal of developing better immunotherapy-based personalized medicine strategies.</p>","PeriodicalId":324902,"journal":{"name":"Journal of Clinical Neurology (Seoul, Korea)","volume":" ","pages":"3-13"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/b0/jcn-18-3.PMC8762502.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Neurology (Seoul, Korea)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3988/jcn.2022.18.1.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

Glioma remains the most common malignant tumor in the brain and is also the most difficult to treat. Immunotherapy achieving long-lasting tumor remission in multiple cancer types has received considerable attention due to its potential to improve the treatment outcomes of patients with glioma. However, clinical trials have not yet demonstrated major improvements in prognoses, which might be attributable to the extrinsic components and intrinsic mechanisms involved in the tumor microenvironment and immune system. It is particularly noteworthy that there is emerging evidence that current routine treatment modalities and the physical and psychological characteristics of patients have different impacts on the efficacy of glioma immunotherapy. This article addresses how these factors interact with the host immune system and tumor microenvironment, and highlights their potential roles in glioma immunotherapy, with the ultimate goal of developing better immunotherapy-based personalized medicine strategies.

Abstract Image

Abstract Image

一般因素对神经胶质瘤免疫治疗的影响。
神经胶质瘤是大脑中最常见的恶性肿瘤,也是最难治疗的。免疫疗法在多种癌症类型中实现持久的肿瘤缓解已经受到了相当大的关注,因为它有可能改善胶质瘤患者的治疗结果。然而,临床试验尚未证明预后有重大改善,这可能归因于肿瘤微环境和免疫系统涉及的外在成分和内在机制。特别值得注意的是,越来越多的证据表明,目前的常规治疗方式和患者的生理和心理特征对胶质瘤免疫治疗的疗效有不同的影响。本文阐述了这些因子如何与宿主免疫系统和肿瘤微环境相互作用,并强调了它们在胶质瘤免疫治疗中的潜在作用,最终目标是开发更好的基于免疫治疗的个性化医疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信