Incidence of Restenosis Following Rapamycin or Paclitaxeleluting Stent in Coronary Stent Implantation.

Q2 Medicine

Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2021-01-01 DOI:10.2174/1871529X21666211209115126

Amir Shakarami

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引用次数: 3

Abstract

Background: Coronary artery disease (CAD) is chiefly characterized by atherosclerosis and plaque formation in coronary arteries. The aim of this study was to evaluate the correlation of coronary anatomy as a predictor of restenosis and stent thrombosis in coronary artery disease (CAD) patients 5 years after percutaneous coronary intervention (PCI).

Methods: In this prospective study, 1070 patients with stent restenosis or stent thrombosis over past 5 years were enrolled. Coronary angiography was performed to evaluate coronary restenosis and stent thrombosis 5 years after PCI. Stent restenosis was defined as >50% angiographic in-stent lumen reduction. Stent thrombosis was defined as sudden complete occlusion of stent presenting with acute myocardial infarction in that territory. Demographic data, clinical features and anatomic factors were prospectively reviewed. Baseline, procedural, and post-procedural characteristics of patients were recorded for analysis.

Results: Among demographic characteristics, cardiovascular risk factors (hypertension and diabetes mellitus) and anatomic factors were predictive risk factors for restenosis/thrombosis, p=0.001. The most common site for stent restenosis was proximal to the mid part of the LAD artery, followed by RCA and LCX. A greater diameter of LCX, a greater angle of LM-LAD than LM-LCX and left dominancy increase the incidence of LAD stent restenosis/thrombosis. In this study, the least common restenosis/thrombosis rate in relation to the total number of PCI was in the Ramus intermedius artery.

Conclusion: The outcomes of the study indicated that anatomic factors can predict increased risk of restenosis among CAD patients who underwent PCI.

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冠状动脉支架植入术中雷帕霉素或紫杉醇洗脱支架后再狭窄的发生率。

背景:冠状动脉疾病(CAD)主要以冠状动脉粥样硬化和斑块形成为特征。本研究的目的是评估冠状动脉解剖与冠状动脉疾病(CAD)患者经皮冠状动脉介入治疗(PCI)后5年再狭窄和支架血栓形成的相关性。方法:在这项前瞻性研究中，纳入了1070例过去5年内发生支架再狭窄或支架血栓形成的患者。行冠脉造影评估PCI术后5年冠脉再狭窄及支架血栓形成情况。支架内再狭窄定义为支架内腔缩小50%以上。支架血栓被定义为支架突然完全闭塞，在该区域表现为急性心肌梗死。对人口学资料、临床特征和解剖学因素进行前瞻性回顾。记录患者的基线、手术过程和手术后特征以供分析。结果:在人口学特征中，心血管危险因素(高血压和糖尿病)和解剖因素是再狭窄/血栓形成的预测危险因素，p=0.001。支架再狭窄最常见的部位是LAD动脉近中部，其次是RCA和LCX。LCX直径增大、LM-LAD角度大于LM-LCX、左优势增加了LAD支架再狭窄/血栓的发生率。在本研究中，与PCI总次数相关的再狭窄/血栓发生率最低的是中间支动脉。结论:本研究结果表明解剖因素可以预测行PCI的冠心病患者再狭窄的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.