Ourania Christodoulou, Ioannis Maragkos, Vassiliki Antonakou, Myrto Denaxa
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引用次数: 5
Abstract
The cerebral cortex contains two main neuronal cell populations: the excitatory pyramidal neurons and the inhibitory interneurons, which constitute 20-30% of all cortical neurons. Cortical interneurons are characterized by a remarkable morphological, molecular and functional diversity. A swathe of research activity over the last 20 years has sought to determine how cortical interneurons acquire their mature cellular and functional features, and has identified a number of transcription factors that function at different stages of interneuron development. Here, we review all current knowledge concerning the multiple functions of the "master regulator" - LIM-Homeodomain transcription factor Lhx6 - a gene expressed in the medial ganglionic eminence of the basal telencephalon that controls the development of somatostatin and parvalbumin expressing interneurons.
期刊介绍：
The International Journal of Developmental Biology (ISSN: 0214-
6282) is an independent, not for profit scholarly journal, published by
scientists, for scientists. The journal publishes papers which throw
light on our understanding of animal and plant developmental mechanisms in health and disease and, in particular, research which elucidates the developmental principles underlying stem cell properties
and cancer. Technical, historical or theoretical approaches also fall
within the scope of the journal. Criteria for acceptance include scientific excellence, novelty and quality of presentation of data and illustrations. Advantages of publishing in the journal include: rapid
publication; free unlimited color reproduction; no page charges; free
publication of online supplementary material; free publication of audio
files (MP3 type); one-to-one personalized attention at all stages
during the editorial process. An easy online submission facility and an
open online access option, by means of which papers can be published without any access restrictions. In keeping with its mission, the
journal offers free online subscriptions to academic institutions in
developing countries.
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