Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

The Journal of Infectious Diseases Pub Date : 2022-08-12 DOI:10.1093/infdis/jiac001

Jonas Henrik Kristensen, Rasmus Bo Hasselbalch, Mia Pries-Heje, Pernille Brok Nielsen, Andreas Dehlbæk Knudsen, Kamille Fogh, Jakob Boesgaard Norsk, Aleksander Eiken, Ove Andersen, Thea Kølsen Fischer, Claus Antonio Juul Jensen, Christian Torp-Pedersen, Jørgen Rungby, Sisse Bolm Ditlev, Ida Hageman, Rasmus Møgelvang, Mikkel Gybel-Brask, Ram Benny Dessau, Erik Sørensen, Lene Harritshøj, Fredrik Folke, Maria Elizabeth Engel Møller, Thomas Benfield, Henrik Ullum, Charlotte Sværke Jørgensen, Sisse Rye Ostrowski, Susanne Dam Nielsen, Henning Bundgaard, Kasper Iversen

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引用次数: 4

Abstract

Background: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).

Methods: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.

Results: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.

Conclusions: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.

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流感疫苗接种对2019冠状病毒病风险的影响:一项对4.6万名医护人员的前瞻性队列研究

背景:本研究的目的是评估流感疫苗接种是否对2019冠状病毒病(COVID-19)的风险有影响。方法:对46 112名医护人员进行SARS-CoV-2抗体检测，填写COVID-19症状、住院情况和流感疫苗接种情况调查。结果:2019/2020年流感疫苗接种者与未接种者因SARS-CoV-2住院的风险比为1.00(置信区间为0.56 ~ 1.78,P = 1.00)。同样，没有发现流感疫苗接种对SARS-CoV-2抗体产生的临床影响。结论:流感疫苗接种对SARS-CoV-2和COVID-19感染风险无影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Infectious Diseases

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