The role of prostate inflammation in the pathogenesis of urethral strictures occurring after transurethral resections

IF 0.8 4区医学 Q4 ANDROLOGY

Revista Internacional De Andrologia Pub Date : 2022-04-01 DOI:10.1016/j.androl.2020.10.009

Arif Aydın , Pembe Oltulu , Mehmet Balasar , Mehmet Giray Sönmez , Hakan Hakkı Taşkapu , Mehmet Serkan Özkent , Fahriye Kılınç

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引用次数: 1

Abstract

Objective

To make an extensive evaluation about the effects of histopathological findings acquired from the resection materials of patients who underwent transurethral resection of prostate (TUR-P) due to benign prostate hyperplasia (BPH) on postoperative urethral stricture formation.

Materials and methods

Among patients who had TUR-P due to BPH and were followed up for minimum 6 months, 51 patients detected to have urethral stricture based on endoscopic imaging were included in the urethral stricture group (Group 1) and 52 patients without urethral stricture were included in the control group (Group 2). The relation between histopathological findings of TURP materials and postoperative stricture occurrence was investigated.

Results

No difference in age, prostate volume, operation time and postoperative catheterization time was detected among the groups (p = 0.86, p = 0.13, p = 0.06, p = 0.32, respectively). Average time until the urethral stricture diagnosis in the group with urethral stricture was measured as 57.9 ± 27.2 days. In our study, inflammation intensity in peri-urethral, stromal and periglandular areas and intraglandular destruction ratios were higher in urethral stricture group (Group 1) (p = 0.048, p = 0.3, p = 0.03, p = 0.01, respectively). Again, it was detected that neutrophil, plasmocyte and eosinophil cell ratios were higher in peri-urethral, stromal and periglandular areas and lymphocyte values were lower compared to the control group.

Conclusion

Acquired data has shown that acute inflammatory attacks may be related to urethral stricture with a mostly chronic inflammation background in the prostate. During histopathological examination of prostate tissue acquired through TURP, especially high peri-urethral neutrophil, plasmocyte and eosinophil cell ratios and intra-glandular destruction ratios are important for predicting postoperative urethral stricture occurrences.

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前列腺炎症在经尿道切除术后尿道狭窄发病机制中的作用

目的广泛评价良性前列腺增生(BPH)行经尿道前列腺切除术(turp)患者术后尿道狭窄形成的病理组织学表现。材料与方法在前列腺增生引起的TURP - p患者中，经内镜检查发现尿道狭窄的患者51例作为尿道狭窄组(1组)，无尿道狭窄的患者52例作为对照组(2组)。探讨TURP材料的组织病理学表现与术后狭窄发生的关系。结果两组患者年龄、前列腺体积、手术时间、术后置管时间差异无统计学意义(p = 0.86、p = 0.13、p = 0.06、p = 0.32)。尿道狭窄组至确诊尿道狭窄的平均时间为57.9±27.2天。在我们的研究中，尿道狭窄组(1组)尿道周围、间质和腺周区域的炎症强度和腺内破坏率较高(p = 0.048, p = 0.3, p = 0.03, p = 0.01)。同样，与对照组相比，尿道周围、间质和腺周的中性粒细胞、浆细胞和嗜酸性细胞比例较高，淋巴细胞值较低。结论急性炎症发作可能与尿道狭窄有关，且多为前列腺慢性炎症背景。在经TURP获得的前列腺组织的组织病理学检查中，特别是高的尿道周围中性粒细胞、浆细胞和嗜酸性细胞比率和腺内破坏比率对预测术后尿道狭窄的发生具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Internacional De Andrologia ANDROLOGY-

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： Revista Internacional de Andrología es la revista oficial de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA), la Sociedade Portuguesa de Ardrologia, la Sociedad Argentina de Andrología (SAA), la Asociación Iberoamericana de Sociedades de Andrología (ANDRO), y la Federación Española de Sociedades de Sexología. La revista publicada trimestralmente es revisada por pares y es líder en el la especialidad y en español y portugués. Recientemente también publica artículos en inglés. El objetivo de la revista es principalmente la promoción del conocimiento y la educación médica continua, con un enfoque especial en el público español y latinoamericano, a través de la publicación de las contribuciones importantes de la investigación en el campo. Todos los miembros de las sociedades antes mencionadas reciben la revista y otros suscriptores individuales e institucionales de España, Portugal y América Latina.