The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: an experimental study.
Hamideh Pirami, Ali Khavanin, Farshad Nadri, Ali Tajpoor, Younes Mehrifar, Zohreh Mazaheri Tirani
{"title":"The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: an experimental study.","authors":"Hamideh Pirami, Ali Khavanin, Farshad Nadri, Ali Tajpoor, Younes Mehrifar, Zohreh Mazaheri Tirani","doi":"10.1080/19338244.2021.2011085","DOIUrl":null,"url":null,"abstract":"<p><p>Due to the high prevalence of noise and vibration exposure in most industries, this study aimed to investigate the effects of simultaneous exposure to noise and vibration on sex hormone levels and fertility capacity in rats, as well as the protective effects of the hydroalcoholic extract of cinnamon. In this experimental study, 64 adult male rats were randomly divided into 8 groups, control, noise (N), cinnamon (C), noise + cinnamon (NC), vibration (V), vibration + cinnamon (VC), noise + vibration (NV) and groups Noise + Vibration + Cinnamon (NVC). Groups C, NC, VC and NVC received a 75 mg/kg dose of cinnamon extract by gavage. The rats of groups N and NC, V and VC and NV and NVC were each exposed to noise at 100 dB (700-5700 Hz), vibration acceleration of 1 m/s<sup>2</sup> rms (frequency range of 4-8 Hz), and simultaneously exposed to vibration and noise for 8 hours continuously every night (23:00-7:00) for 50 consecutive nights. Next, a blood sample was taken from the lateral tail vein and the levels of LH, FSH and testosterone were measured with ELISA kits. Each male rat was caged with 3 female rats for one week. The pregnant rats were kept until all of the rat pups were born. Then the fertility capacity, the total number of births, the live births and the birth weight of the rat pups were analyzed with the software SPSS. In the N and NV groups, compared to the control group, a significant decrease in LH and testosterone levels, the number of births and the birth weight was observed (<i>p</i> < 0.05). A significant decrease in testosterone levels, number of births and birth weight was observed in Group V compared to the control group (<i>p</i> < 0.05). In addition, significant increases in LH, FSH and testosterone levels and in birth weight were observed in group C compared to the control group (<i>p</i> < 0.05). Significant increases in FSH and testosterone levels, birth weight, and the number of births were noted in the NVC group compared to the NV group (<i>p</i> < 0.05). Based on the results of this study, cinnamon extract could alleviate the destructive effects of noise and vibration (both individually and in combination) on levels of sex hormones (LH, FSH, and testosterone), the number of births, and birth weight.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"77 9","pages":"764-773"},"PeriodicalIF":1.4000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Environmental & Occupational Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/19338244.2021.2011085","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 1
Abstract
Due to the high prevalence of noise and vibration exposure in most industries, this study aimed to investigate the effects of simultaneous exposure to noise and vibration on sex hormone levels and fertility capacity in rats, as well as the protective effects of the hydroalcoholic extract of cinnamon. In this experimental study, 64 adult male rats were randomly divided into 8 groups, control, noise (N), cinnamon (C), noise + cinnamon (NC), vibration (V), vibration + cinnamon (VC), noise + vibration (NV) and groups Noise + Vibration + Cinnamon (NVC). Groups C, NC, VC and NVC received a 75 mg/kg dose of cinnamon extract by gavage. The rats of groups N and NC, V and VC and NV and NVC were each exposed to noise at 100 dB (700-5700 Hz), vibration acceleration of 1 m/s2 rms (frequency range of 4-8 Hz), and simultaneously exposed to vibration and noise for 8 hours continuously every night (23:00-7:00) for 50 consecutive nights. Next, a blood sample was taken from the lateral tail vein and the levels of LH, FSH and testosterone were measured with ELISA kits. Each male rat was caged with 3 female rats for one week. The pregnant rats were kept until all of the rat pups were born. Then the fertility capacity, the total number of births, the live births and the birth weight of the rat pups were analyzed with the software SPSS. In the N and NV groups, compared to the control group, a significant decrease in LH and testosterone levels, the number of births and the birth weight was observed (p < 0.05). A significant decrease in testosterone levels, number of births and birth weight was observed in Group V compared to the control group (p < 0.05). In addition, significant increases in LH, FSH and testosterone levels and in birth weight were observed in group C compared to the control group (p < 0.05). Significant increases in FSH and testosterone levels, birth weight, and the number of births were noted in the NVC group compared to the NV group (p < 0.05). Based on the results of this study, cinnamon extract could alleviate the destructive effects of noise and vibration (both individually and in combination) on levels of sex hormones (LH, FSH, and testosterone), the number of births, and birth weight.
由于噪音和振动暴露在大多数工业中普遍存在，本研究旨在探讨噪音和振动同时暴露对大鼠性激素水平和生育能力的影响，以及肉桂水酒精提取物的保护作用。实验选用成年雄性大鼠64只，随机分为8组:对照组、噪声(N)、肉桂(C)、噪声+肉桂(NC)、振动(V)、振动+肉桂(VC)、噪声+振动(NV)和噪声+振动+肉桂(NVC)组。C组、NC组、VC组和NVC组灌胃肉桂提取物75 mg/kg。N和NC组、V和VC组、NV和NVC组大鼠分别暴露于100 dB (700 ~ 5700 Hz)、振动加速度1 m/s2 rms(频率范围4 ~ 8 Hz)的噪声环境中，每晚(23:00 ~ 7:00)连续8小时同时暴露于振动和噪声环境中，连续50夜。然后，从尾侧静脉取血，用ELISA试剂盒检测黄体生成素、卵泡刺激素和睾酮水平。每只雄性大鼠与3只雌性大鼠笼养1周。怀孕的大鼠一直饲养到所有的幼鼠出生。然后用SPSS软件对大鼠的生育能力、产仔总数、活产数和出生重进行分析。在N和NV组中，与对照组相比，观察到LH和睾酮水平，分娩次数和出生体重显著降低(p p p p p)
期刊介绍：
Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
