Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.

IF 3.1 3区农林科学 Q1 VETERINARY SCIENCES

Ilar Journal Pub Date : 2021-12-31 DOI:10.1093/ilar/ilab022

Timothy K Cooper, David K Meyerholz, Amanda P Beck, Martha A Delaney, Alessandra Piersigilli, Teresa L Southard, Cory F Brayton

{"title":"Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.","authors":"Timothy K Cooper, David K Meyerholz, Amanda P Beck, Martha A Delaney, Alessandra Piersigilli, Teresa L Southard, Cory F Brayton","doi":"10.1093/ilar/ilab022","DOIUrl":null,"url":null,"abstract":"<p><p>Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of \"normal\" and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits.</p>","PeriodicalId":56299,"journal":{"name":"Ilar Journal","volume":"62 1-2","pages":"77-132"},"PeriodicalIF":3.1000,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291387/pdf/ilab022.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ilar Journal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1093/ilar/ilab022","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 2

Abstract

Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of "normal" and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits.

查看原文本刊更多论文

实验室小鼠、大鼠、沙鼠、豚鼠、仓鼠、裸鼹鼠和兔子的相关条件和病理学研究。

在生物医学研究中，动物是研究生物过程、疾病发病机制、治疗干预、安全性、毒性和致癌性的宝贵资源。对动物数据的解释不仅需要了解所研究的过程或疾病(病理生理学)，还需要认识到可能影响或混淆研究结果的自发条件和背景病变(病理学)。物种、品系/种群、性别、年龄、解剖学、生理学、自发性疾病(非传染性和传染性)和瘤变影响实验结果和解释以及动物福利。本综述和所选的参考文献旨在为研究人员、病理学家和兽医人员提供病理学资源，他们努力实现研究的严谨性和有效性，必须了解“正常”和预期条件的范围，以准确识别与研究相关的实验表型，以及异常疾病、病理或其他可能危及实验室小鼠、大鼠、沙鼠、豚鼠、仓鼠、裸鼹鼠和兔子研究的条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ilar Journal 农林科学-兽医学

CiteScore

5.10

自引率

20.00%

发文量

审稿时长

>18 weeks

期刊介绍： The ILAR Journal is the peer-reviewed, theme-oriented publication of the Institute for Laboratory Animal Research (ILAR), which provides timely information for all who study, use, care for, and oversee the use of animals in research. The journal publishes original articles that review research on animals either as direct subjects or as surrogates for humans. According to policy, any previously unpublished animal research reported in the ILAR Journal will have been conducted according to the scientific, technical, and humanely appropriate guidelines current at the time the research was conducted in accordance with the Guide for the Care and Use of Laboratory Animals or other guidance provided by taxonomically-oriented professional societies (e.g., American Society of Mammalogy) as referenced in the Guide.