The relationship between mean platelet volume and resistant hypertension.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-04-03 Epub Date: 2022-01-03 DOI:10.1080/10641963.2021.2022686

Halil Akın, Önder Bilge, Bünyamin Yavuz, Selçuk Özkan, Ferhat Işık

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引用次数: 4

Abstract

Objective: Resistant hypertension (RH) is associated with an increased risk of cardiovascular events.Mean platelet volume (MPV) has been shown to indicate platelet activation and is associated with increased cardiovascular disease risk. In our study, we aimed to evaluate the relationship between mean platelet volume and resistant hypertension.

Method: A total of 279 patientswere included in our study and divided into three groups (GroupI: seventy-eight patients with resistant hypertension, group II: seventy-nine patients with controlled hypertension and group III: one-hundred-five patients without hypertension). Routine laboratory tests and ambulatory blood pressure measurement (ABPM) were followed up in all patients.

Results: Of the patients in the study, 25% were female while 75% were male, and the mean age was 56.5 ± 11.8 years. The mean MPV values were found to be 9.34 ± 1.49 fL in the RHT group, 8.82 ± 0.83 fLin the controlled HT group, and 8.5 ± 0.85 fL in the normotensive individuals, and there was a significant correlation between the RHT group and the other groups (RHT versus controlled HT p1 = 0.008, RHT versus normotensive individuals p2 < 0,001). When we compared controlled HT and normotensive individuals, no significant relationship was found between MPV values (p3 = 0,157).

Conclusion: The MPV value was found to be higher in resistant hypertensive patients compared to controlled hypertensive and normotensive patients. MPV values can be used to predict adverse cardiovascular events in RHT patients.

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平均血小板体积与顽固性高血压的关系。

目的:顽固性高血压(RH)与心血管事件风险增加相关。平均血小板体积(MPV)显示血小板活化，并与心血管疾病风险增加有关。在我们的研究中，我们旨在评估平均血小板体积与顽固性高血压的关系。方法:将279例患者分为3组(顽固性高血压患者78例，控制高血压患者79例，无高血压患者105例)。随访所有患者的常规实验室检查和动态血压测量(ABPM)。结果:本组患者中女性占25%，男性占75%，平均年龄56.5±11.8岁。RHT组MPV均值为9.34±1.49 fL，对照组为8.82±0.83 fL，正常血压组为8.5±0.85 fL，且与其他组有显著相关性(RHT与对照组p1 = 0.008, RHT与正常血压组p2)。结论:高血压抵抗组MPV值高于高血压控制组和正常血压组。MPV值可用于预测RHT患者的不良心血管事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.