Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Julia Doroszkiewicz, Piotr Mroczko, Agnieszka Kulczyńska-Przybik
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引用次数: 3

Abstract

Alzheimer's disease is a progressive and deadly neurodegenerative disorder and one of the most common causes of dementia globally. Current, insufficiently sensitive and specific methods of early diagnosing and monitoring this disease prompt a search for new tools. Numerous literature data have indicated that the pathogenesis of Alzheimer's disease (AD) is not limited to the neuronal compartment but involves various immunological mechanisms. Neuroinflammation has been recognized as a very important process in AD pathology. It seems to play pleiotropic roles, both neuroprotective and neurodegenerative, in the development of cognitive impairment depending on the stage of the disease. Mounting evidence demonstrates that inflammatory proteins could be considered biomarkers of disease progression. Therefore, the present review summarizes the role of some inflammatory molecules and their potential utility in detecting and monitoring dementia severity. This paper also provides a valuable insight into new mechanisms leading to the development of dementia, which might be useful in discovering possible anti-inflammatory treatment.

Abstract Image

中枢神经系统炎症:了解阿尔茨海默病发病机制的各个方面。
阿尔茨海默病是一种进行性和致命的神经退行性疾病,是全球痴呆症最常见的原因之一。目前,早期诊断和监测这种疾病的方法不够敏感和具体,这促使人们寻找新的工具。大量文献资料表明,阿尔茨海默病(AD)的发病机制并不局限于神经元间室,而是涉及多种免疫机制。神经炎症已被认为是阿尔茨海默病的一个重要病理过程。它似乎在认知障碍的发展中发挥着多效作用,既具有神经保护作用,也具有神经退行性作用,这取决于疾病的阶段。越来越多的证据表明,炎症蛋白可以被认为是疾病进展的生物标志物。因此,本文综述了一些炎症分子的作用及其在检测和监测痴呆严重程度方面的潜在用途。这篇论文还对导致痴呆发展的新机制提供了有价值的见解,这可能有助于发现可能的抗炎治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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