Canonical Chinese medicine formula Danzhi-Xiaoyao-San for treating depression: A systematic review and meta-analysis

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2022-04-06 Epub Date: 2021-12-28 DOI:10.1016/j.jep.2021.114960

Xiao-Le Wang , Si-Tong Feng , Ya-Ting Wang , Ning-Ning Zhang , Zhen-Zhen Wang , Yi Zhang

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引用次数: 13

Abstract

Ethnopharmacological relevance

Danzhi-Xiaoyao-San (DXS), as a canonical Chinese medicine formula, possessing the functions of the soothing liver, invigorating spleen, clearing heat, and cooling blood, has been widely used for the treatment of depression.

Aim of the study

This systematic review and meta-analysis of randomized controlled trials aimed to examine the efficacy of DXS in depression.

Materials and methods

We performed a literature search in several databases, e.g., PUBMED, until August 2021 and conducted the meta-analysis using Review Manager 5.3 software. The random-effects model and fixed-effects model were used to synthetize extracted data.

Results

Finally, this meta-analysis showed that comparing with antidepressants, DXS exhibited similar effect to antidepressants in the clinical comprehensive effect [RR = 1.04, 95% CI (0.77, 1.40); P = 0.81] and decrease in Self-Rating Depression Scale scores [WMD = 0.89, 95% CI (−6.33, 8.11); P = 0.81], while lower effect in Hamilton Depression Scale scores [SMD = −0.29, 95% CI (−0.55, −0.03); P = 0.03]; Furthermore, DXS plus antidepressants can significantly improve the clinical comprehensive effect [RR = 1.23, 95% CI (1.17, 1.29); P < 0.00001] and decrease the Hamilton Depression Scale scores [SMD = 1.04, 95% CI (0.51, 1.58); P = 0.0001] than pure antidepressants.

Conclusion

This systematic review and meta-analysis approved an efficient role of DXS in improving depression in clinical randomized controlled trials. However, further evidence from large samples and high-quality randomized controlled trials is needed to be investigated for a reliable conclusion about DXS in the treatment of depression.

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查看原文本刊更多论文

中药复方丹栀逍遥散治疗抑郁症的系统评价与meta分析

丹栀逍遥散(DXS)是一种具有平肝健脾、清热凉血等功效的经典中药方剂，被广泛用于治疗抑郁症。本研究旨在对随机对照试验进行系统回顾和荟萃分析，以检验DXS治疗抑郁症的疗效。材料和方法我们在PUBMED等多个数据库中进行文献检索，直到2021年8月，并使用Review Manager 5.3软件进行meta分析。采用随机效应模型和固定效应模型对提取的数据进行综合处理。结果最后，本荟萃分析显示，与抗抑郁药相比，DXS的临床综合疗效与抗抑郁药相似[RR = 1.04, 95% CI (0.77, 1.40);P = 0.81]且抑郁自评量表得分下降[WMD = 0.89, 95% CI (- 6.33, 8.11);P = 0.81]，而汉密尔顿抑郁量表评分的影响较低[SMD = - 0.29, 95% CI (- 0.55， - 0.03);p = 0.03];DXS联合抗抑郁药可显著提高临床综合疗效[RR = 1.23, 95% CI (1.17, 1.29);P & lt;0.00001]并降低汉密尔顿抑郁量表得分[SMD = 1.04, 95% CI (0.51, 1.58);P = 0.0001]。结论本系统综述和荟萃分析在临床随机对照试验中证实了DXS在改善抑郁症方面的有效作用。然而，对于DXS治疗抑郁症的可靠结论，需要来自大样本和高质量随机对照试验的进一步证据进行调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.