PREDICTORS OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AFTER TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Satoshi Yasuhara, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Ayako Takahashi, Tomotaka Wakazono, Kenji Yamashiro, Akitaka Tsujikawa
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引用次数: 2

Abstract

Purpose: The purpose of this study was to investigate the predictors of retinal pigment epithelium (RPE) tear development after treatment for neovascular age-related macular degeneration using swept source optical coherence tomography angiography.

Methods: This prospective study included 152 treatment-naïve eyes with neovascular age-related macular degeneration without high myopia that were followed up for 1 year after treatment. Eligible eyes were classified into eyes with or without RPE tear development. They were matched in a 1:2 ratio. The areas of choroidal neovascularization (CNV) and RPE detachment (pigment epithelial detachment [PED]) were measured from optical coherence tomography angiography and OCT en face images, respectively. The optical coherence tomography angiography-specific parameters representing CNV status were analyzed.

Results: Eight (5.3%) of the 152 eyes developed RPE tears (RPE tear group). After matching, 16 eyes without RPE tears were analyzed (non-RPE tear group). The ratio of the CNV/PED area was lower in the RPE tear group than that in the non-RPE tear group (P = 0.007). The PED area was broader (P = 0.008), and PED height was greater in the RPE tear group (P = 0.04). Optical coherence tomography angiography-specific parameters did not differ between the two groups.

Conclusion: Neovascular age-related macular degeneration with pretreatment broad PED, high PED, and small CNV area relative to the PED area has a high risk of RPE tear development after therapy. However, CNV status may not have an association.

使用扫源光学相干断层血管造影治疗新生血管性年龄相关性黄斑变性后视网膜色素上皮撕裂发展的预测因素。
目的:本研究的目的是研究扫描源光学相干断层血管造影治疗新生血管性年龄相关性黄斑变性后视网膜色素上皮(RPE)撕裂发展的预测因素。方法:本前瞻性研究纳入152只treatment-naïve眼的新生血管性年龄相关性黄斑变性,无高度近视,治疗后随访1年。符合条件的眼睛分为有或没有RPE泪液发育的眼睛。它们以1:2的比例匹配。分别通过光学相干断层扫描血管造影和OCT面部图像测量脉络膜新生血管(CNV)和色素上皮脱离(RPE)的面积。分析了代表CNV状态的光学相干断层血管造影特定参数。结果:152眼中8眼(5.3%)发生RPE撕裂(RPE撕裂组)。匹配后,分析16只无RPE泪眼(非RPE泪眼组)。RPE撕裂组的CNV/PED面积比低于非RPE撕裂组(P = 0.007)。RPE撕裂组PED面积更宽(P = 0.008), PED高度更大(P = 0.04)。光学相干断层成像血管造影的特定参数在两组之间没有差异。结论:经预处理的新生血管性年龄相关性黄斑变性患者,PED宽、PED高、CNV面积相对于PED面积小,治疗后发生RPE撕裂的风险较高。然而,CNV状态可能没有关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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