Oral Ibandronate Therapy in Three Patients with Osteogenesis Imperfecta.

Q3 Medicine
Štěpán Kutílek, Ivana Plášilová, Sylva Skálová, Milan Bayer, Erika Ondrušová
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引用次数: 1

Abstract

Introduction: Treatment with orally administered ibandronate is an effective way to increase bone mineral density (BMD) and reduce fracture rate in post-menopausal women and in men with osteoporosis. There are only very few reports concerning ibandronate therapy in children and adolescents, and in patients with osteogenesis imperfecta (OI), as bisphosphonates are not registered for therapeutic use in pediatrics.

Case report: We present three patients with OI, where once-monthly oral ibandronate increased spinal BMD after two and four years, respectively, of therapy without any occurrence of new fractures and no adverse reactions. Somatic growth was not affected by the ibandronate treatment.

Conclusion: Once-monthly oral ibandronate increased BMD and most probably improved bone quality in young patients with OI.

口服依班膦酸盐治疗成骨不全症3例。
口服依班膦酸盐治疗是提高绝经后女性和骨质疏松症男性骨密度和降低骨折率的有效方法。关于儿童和青少年以及成骨不全症(OI)患者使用依班膦酸盐治疗的报道很少,因为双膦酸盐并未注册用于儿科治疗。病例报告:我们报告了3例成骨不全患者,分别在治疗2年和4年后,每月一次口服依班膦酸盐增加了脊柱骨密度,没有发生任何新的骨折,也没有不良反应。依班膦酸盐处理对体生长无影响。结论:每月一次口服依班膦酸盐可增加年轻成骨不全患者的骨密度,并极有可能改善骨质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta medica (Hradec Kralove)
Acta medica (Hradec Kralove) Medicine-Medicine (all)
CiteScore
1.10
自引率
0.00%
发文量
8
审稿时长
20 weeks
期刊介绍: Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."
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