Temporal Interference Stimulation Regulates Eye Movements and Neural Activity in the Mice Superior Colliculus^.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Pub Date : 2021-11-01 DOI:10.1109/EMBC46164.2021.9629968

Sixian Song, Jiajia Zhang, Yi Tian, Liping Wang, Pengfei Wei

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引用次数: 5

Abstract

Temporal interference (TI) stimulation is a novel electrical stimulation technique which offers noninvasive deep brain stimulation (NDBS) in mice. The purpose of this study is to investigate the effect of TI stimulation on deep layers superior colliculus (SC) nerve activity and eye movements in mice. Six male C57BL / 6J mice were used in this study. Different parameters of TI stimulation were applied to the deep layers of mice SC. Each TI stimulation lasted for 20 seconds and were repeated five times. We analyzed the synchronous recording of Ca²⁺ signals in deep layers mice SC and the eye movement amplitudes. Our results show that TI stimulation can evoke eye movements and the neural activity in deep layers of mice SC. Changing the difference frequency of TI stimulation can regulate the frequency of the nerve activity and eye movements. Granger causality analysis indicates that the neural activity in deep layers of mice SC may cause the eye movements during TI stimulation.

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时间干扰刺激调节小鼠上丘眼运动和神经活动。

时间干扰(TI)刺激是一种新型的电刺激技术，可对小鼠进行无创脑深部电刺激。本研究旨在探讨TI刺激对小鼠深层上丘(SC)神经活动和眼动的影响。本研究选用6只雄性C57BL / 6J小鼠。在小鼠SC深层施加不同的TI刺激参数，每次TI刺激持续20秒，重复5次。我们分析了深层小鼠SC内Ca2+信号的同步记录和眼动振幅。结果表明，TI刺激可引起小鼠SC深层的眼动和神经活动，改变TI刺激的差频可以调节神经活动和眼动的频率。格兰杰因果分析表明，小鼠SC深层神经活动可能引起TI刺激时的眼动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

CiteScore

0.80

自引率

0.00%

发文量