Validation of AD8-Philippines (AD8-P): A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines.

Q1 Neuroscience

International Journal of Alzheimer's Disease Pub Date : 2021-10-31 eCollection Date: 2021-01-01 DOI:10.1155/2021/7750235

Jacqueline C Dominguez, Ma Fe P de Guzman, Ma Lourdes C Joson, Krizelle Fowler, Boots P Natividad, Precy S Cruz, Jose Leo Jiloca, Primitivo B Mactal, Jayvee Dyne Dominguez, Jeffrey Domingo, Jhozel Kim Dominguez-Awao, Macario Reandelar, Jem R Javier, ThienKieuThi Phung, John C Morris, James E Galvin

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引用次数: 3

Abstract

Aim: This study was aimed at validating the Filipino version of AD8 (AD8-P).

Methods: Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia.

Results: A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3.

Conclusion: AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.

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ad8 -菲律宾(AD8-P)的验证:一份简短的基于信息的菲律宾痴呆筛查问卷

目的:本研究旨在验证菲律宾版AD8 (AD8- p)。方法:社区居住的菲律宾≥60岁老年人及其举报人参与本研究。心理学家独立采访了AD8-P的举报者，并对老年人进行了菲律宾验证的迷你精神状态检查(MMSE-P)和蒙特利尔认知评估(MoCA-P)。神经学家和老年病专家进行了身体和神经学检查和临床痴呆评分™(CDR™)来确定认知诊断，并对AD8-P结果进行了盲测。痴呆的诊断依据DSM-IV-TR标准。根据DSM-IV-TR痴呆诊断标准评估AD8-P甄别痴呆的能力。结果:本研究共纳入366名年龄≥60岁的菲律宾社区老年人，213名认知正常，153名痴呆患者及其举报者。大多数(90%)处于痴呆的最轻阶段。AD8-P的受试者工作特征曲线下面积(AUROC)为0.94 (95% CI 0.92至0.96)，显示出筛查痴呆的出色总体预测能力。最佳平衡敏感性(91.5%)和特异性(77.9%)的最佳AD8-P临界值≥3。结论:即使在认知能力下降的早期阶段，AD8-P也显示出良好的心理测量学特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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