Prognostic impact of human papillomavirus infection on cervical dysplasia, cancer, and patient survival in Saudi Arabia: A 10-year retrospective analysis.
Fatimah Alhamlan, Dalia Obeid, Hadeel Khayat, Tulbah Asma, Ismail A Al-Badawi, Areej Almutairi, Shihana Almatrrouk, Mohammed Fageeh, Muhammed Bakhrbh, Majed Nassar, Mohammed Al-Ahdal
{"title":"Prognostic impact of human papillomavirus infection on cervical dysplasia, cancer, and patient survival in Saudi Arabia: A 10-year retrospective analysis.","authors":"Fatimah Alhamlan, Dalia Obeid, Hadeel Khayat, Tulbah Asma, Ismail A Al-Badawi, Areej Almutairi, Shihana Almatrrouk, Mohammed Fageeh, Muhammed Bakhrbh, Majed Nassar, Mohammed Al-Ahdal","doi":"10.5144/0256-4947.2021.350","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Data on human papillomavirus (HPV) prevalence and survival rates among HPV-infected women are scarce in Saudi Arabia.</p><p><strong>Objective: </strong>Assess the prevalence of HPV genotypes in cervical biopsy specimens and its effect on survival over a 10-year timeframe.</p><p><strong>Design: </strong>Retrospective, cross-sectional.</p><p><strong>Settings: </strong>Saudi referral hospital.</p><p><strong>Patients and methods: </strong>Cervical biopsy specimens were collected from women aged 23-95 years old who underwent HPV detection, HPV genotyping, p16<sup>INK4a</sup> expression measurement using immunohistochemistry. Kaplan-Meier plots were constructed to analyze overall survival rates.</p><p><strong>Main outcome measures: </strong>Survival rate of HPV-positive cervical cancer patients.</p><p><strong>Sample size: </strong>315 cervical biopsy specimens.</p><p><strong>Results: </strong>HPV was detected in 96 patients (30.4%): 37.3% had cervical cancer; 14.2% cervical intraepithelial neoplasia (CIN) III, 4.1% CIN II, and 17.0% CIN I. A significant association was found between HPV presence and cervical cancer (χ<sup>2</sup>=56.78; <i>P</i><.001). The expression of p16<sup>INK4a</sup> was a significant predictor of survival: women who had p16<sup>INK4a</sup> overexpression had poorer survival rates (multivariate Cox regression, hazard ratio, 3.2; 95% CI, 1.1-8.8). In addition, multivariate models with HPV status and cervical cancer diagnosis showed that HPV status was a significant predictor of survival: HPV-positive women had better survival rates than HPV-negative women.</p><p><strong>Conclusion: </strong>These findings suggest that implementing cervical and HPV screening programs may decrease cervical cancer rates and improve survival rates of women in Saudi Arabia.</p><p><strong>Limitation: </strong>Single center and small sample size.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":"41 6","pages":"350-360"},"PeriodicalIF":1.5000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/56/0256-4947.2021.350.PMC8650596.pdf","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Saudi Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5144/0256-4947.2021.350","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/12/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 5
Abstract
Background: Data on human papillomavirus (HPV) prevalence and survival rates among HPV-infected women are scarce in Saudi Arabia.
Objective: Assess the prevalence of HPV genotypes in cervical biopsy specimens and its effect on survival over a 10-year timeframe.
Design: Retrospective, cross-sectional.
Settings: Saudi referral hospital.
Patients and methods: Cervical biopsy specimens were collected from women aged 23-95 years old who underwent HPV detection, HPV genotyping, p16INK4a expression measurement using immunohistochemistry. Kaplan-Meier plots were constructed to analyze overall survival rates.
Main outcome measures: Survival rate of HPV-positive cervical cancer patients.
Sample size: 315 cervical biopsy specimens.
Results: HPV was detected in 96 patients (30.4%): 37.3% had cervical cancer; 14.2% cervical intraepithelial neoplasia (CIN) III, 4.1% CIN II, and 17.0% CIN I. A significant association was found between HPV presence and cervical cancer (χ2=56.78; P<.001). The expression of p16INK4a was a significant predictor of survival: women who had p16INK4a overexpression had poorer survival rates (multivariate Cox regression, hazard ratio, 3.2; 95% CI, 1.1-8.8). In addition, multivariate models with HPV status and cervical cancer diagnosis showed that HPV status was a significant predictor of survival: HPV-positive women had better survival rates than HPV-negative women.
Conclusion: These findings suggest that implementing cervical and HPV screening programs may decrease cervical cancer rates and improve survival rates of women in Saudi Arabia.
期刊介绍：
The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
