Reappraisal of Grading in Intestinal-Type Sinonasal Adenocarcinoma: Tumor Budding as an Independent Prognostic Parameter.

Head and neck pathology Pub Date : 2022-09-01 Epub Date: 2022-01-11 DOI:10.1007/s12105-022-01410-3
Christian M Meerwein, Muriel D Brada, Michael B Soyka, David Holzmann, Niels J Rupp
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引用次数: 1

Abstract

Since sinonasal intestinal-type adenocarcinomas (ITAC) show resemblance to colorectal adenocarcinomas, we aimed to investigate novel prognostic factors of outcome, with particular focus on the role of tumor budding (TB). Retrospective clinico-pathological single-institution study on consecutive ITAC patients between 1996 and 2020. Histopathological parameters including conventional subtypes and TB features (low, intermediate, high) were evaluated with the aid of pancytokeratin (AE1/AE3) immunohistochemical staining. Parameters were correlated to clinical data and outcome. A total of 31 ITAC patients were included. Overall, 19/31 patients (61.3%) presented with stage III/IV disease. Presence of lymph node or distant metastases was rare (1/31 patient, 3.2%). Treatment protocols consisted of tumor resection in 30/31 patients (96.8%) and primary radiochemotherapy in 1/31 patient (3.2%). Adjuvant radiation therapy was conducted in 20/30 surgically treated patients (66.7%). The 3- and 5-year overall survival (OS) was 83.9% and 78.3% and the 3- and 5-years disease-specific survival (DSS) 83.7% % and 78.5%, respectively. The presence of intermediate/high TB (defined as ≥ 5 buds) was associated with both, worse DSS (log rank p = 0.03) and OS (log rank p = 0.006). No patient with low TB revealed progressive disease or died of the disease. No association between TB and tumor stage or conventional tumor subtype was found. Tumor budding seems to be an independent prognostic factor of worse outcome in ITAC.

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肠型鼻腺癌分级的重新评估:肿瘤出芽作为一个独立的预后参数。
由于鼻鼻肠型腺癌(ITAC)与结直肠腺癌有相似之处,我们旨在研究新的预后因素,特别关注肿瘤出芽(TB)的作用。1996年至2020年间连续ITAC患者的回顾性临床病理单机构研究。通过泛细胞角蛋白(AE1/AE3)免疫组化染色评估组织病理学参数,包括常规亚型和TB特征(低、中、高)。参数与临床数据和结果相关。共纳入31例ITAC患者。总体而言,31名患者中有19名(61.3%)表现为III/IV期疾病。淋巴结或远处转移罕见(1/31例,3.2%)。治疗方案包括30/31例(96.8%)肿瘤切除和1/31例(3.2%)原发性放化疗。30例手术治疗患者中有20例(66.7%)进行了辅助放疗。3年和5年总生存率(OS)分别为83.9%和78.3%,3年和5年疾病特异性生存率(DSS)分别为83.7%和78.5%。中高结核(定义为≥5个芽)的存在与更差的DSS (log rank p = 0.03)和OS (log rank p = 0.006)相关。无低结核患者表现出疾病进展或死亡。结核与肿瘤分期或常规肿瘤亚型无相关性。肿瘤萌芽似乎是ITAC预后较差的独立预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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