Mood disorders in patients with hypersomnia: comparison of sleep-related breathing disorders versus narcolepsy.

Pub Date : 2021-10-01
Branislav Kollar, Pavel Siarnik, Katarína Valovičová, Oto Hanus, Peter Turcani, Katarina Klobucnikova
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引用次数: 0

Abstract

Background: Anxiety and depression are common comorbidities of excessive daytime sleepiness (EDS). Sleep-related breathing disorders (SBD) and central disorders of hypersomnolence (like narcolepsy [NA]) are the most frequent causes of EDS. This study aimed to evaluate mood disorders in NA patients compared to the subjects with EDS due to SBD (SBD-EDS).

Methods: In a retrospective analysis, subjects with NA and SBD-EDS were compared. All subjects underwent overnight polysomnography. NA patients underwent also multiple sleep latency test. Epworth sleepiness scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Becks questionnaire, and Zung depression scale were used to assess EDS, sleep quality, anxiety, and depression, respectively.

Results: We enrolled 24 NA and 41 SBD-EDS subjects. Values of PSQI and Zung scale were significantly worse in the SBD-EDS group than in NA patients (8.34±3.84 vs. 6.83±2.25, p=0.04; 46.86±12.69 vs. 40.81±11.27, p=0.03, respectively). Anxiety was significantly more frequent in SBD-EDS subjects compared to NA (63.4% vs. 37.5%, p=0.04). Out of all observed sleep-related indices, PSQI was the only factor, that significantly correlated with the measures of anxiety in both groups (NA: r=0.65, p=0.001; SBD-EDS: r=0.45, p=0.003) and with the measures of depression in NA subjects (r=0.51, p=0.01). In SBD-EDS group, measures of depression significantly correlated with PSQI (r=0.46, p=0.002), oxygen desaturation index (r=0.35, p=0.03), and ESS (r=0.5, p=0.001).

Conclusion: Compared to NA, our results suggest significantly worse measures of depression and a significantly higher frequency of anxiety in the SBD-EDS population. Measures of anxiety and depression significantly correlated with quality of sleep in both groups.

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嗜睡患者的情绪障碍:睡眠相关呼吸障碍与发作性睡病的比较
背景:焦虑和抑郁是白天过度嗜睡(EDS)的常见合并症。睡眠相关呼吸障碍(SBD)和嗜睡中枢性障碍(如嗜睡症[NA])是EDS最常见的病因。本研究旨在评估NA患者与因SBD引起的EDS患者的情绪障碍(SBD-EDS)。方法:回顾性分析NA和SBD-EDS患者。所有受试者都进行了夜间多导睡眠描记。NA患者还进行了多次睡眠潜伏期测试。采用Epworth嗜睡量表(ESS)、匹兹堡睡眠质量指数(PSQI)、Becks问卷和Zung抑郁量表分别评估EDS、睡眠质量、焦虑和抑郁。结果:入组NA 24例,SBD-EDS 41例。SBD-EDS组PSQI、Zung评分值显著低于NA组(8.34±3.84∶6.83±2.25,p=0.04;46.86±12.69∶40.81±11.27,p=0.03)。与NA相比,SBD-EDS患者的焦虑发生率明显更高(63.4%比37.5%,p=0.04)。在所有观察到的睡眠相关指标中,PSQI是唯一与两组患者焦虑测量值显著相关的因素(NA: r=0.65, p=0.001;SBD-EDS: r=0.45, p=0.003),与NA受试者抑郁程度相关(r=0.51, p=0.01)。在SBD-EDS组中,抑郁指标与PSQI (r=0.46, p=0.002)、氧去饱和指数(r=0.35, p=0.03)和ESS (r=0.5, p=0.001)显著相关。结论:与NA相比,我们的研究结果表明SBD-EDS人群的抑郁测量明显更差,焦虑频率明显更高。在两组中,焦虑和抑郁的测量结果与睡眠质量显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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