The clinical course of Rathke's cleft cysts in pediatric patients: impact on growth and pubertal development.

IF 1 Q4 ENDOCRINOLOGY & METABOLISM

Clinical Pediatric Endocrinology Pub Date : 2022-01-01 Epub Date: 2021-11-01 DOI:10.1297/cpe.2021-0034

Yousuke Higuchi, Kosei Hasegawa, Toshihide Kubo, Hiroyuki Tanaka, Hirokazu Tsukahara

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引用次数: 1

Abstract

Rathke's cleft cysts (RCCs) are non-neoplastic epithelial lesions in the sellar or suprasellar regions. RCCs are usually asymptomatic; however, some patients experience headaches, visual disturbances, and endocrine disorders. The best treatment for associated endocrinopathy remains elusive. We aimed to investigate the clinical course, magnetic resonance imaging findings, and response to therapy in 10 pediatric patients with RCCs and endocrinopathy. Growth impairment and precocious puberty were observed to be prevalent. One patient with suprasellar extension of RCC underwent surgery, while the others were treated medically. Of the nine patients, seven patients showed stable cyst size, while two patients displayed reduction in cyst size. Hormone replacement and gonadotropin suppression therapy were found to be effective. Imaging and endocrine follow-ups are warranted because of the potential for changes in the cyst size and hormonal changes.

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儿童Rathke氏裂囊肿的临床过程:对生长和青春期发育的影响。

Rathke's cleft囊肿(RCCs)是鞍区或鞍上区域的非肿瘤性上皮病变。rcc通常无症状;然而，一些患者会出现头痛、视觉障碍和内分泌紊乱。治疗相关内分泌疾病的最佳方法仍然难以捉摸。我们的目的是研究10例患有rcc和内分泌病变的儿童患者的临床病程、磁共振成像结果和对治疗的反应。生长障碍和性早熟普遍存在。一名患有肾细胞癌鞍上延伸的患者接受了手术，而其他患者则接受了药物治疗。9例患者中，7例囊肿大小稳定，2例囊肿大小减小。激素替代和促性腺激素抑制治疗是有效的。由于囊肿大小和激素变化的潜在变化，影像学和内分泌随访是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

2.40

自引率

7.10%

发文量